Patterns of stress-related change in salivary alpha-amylase and cortisol among young children: Associations with maternal psychosocial risk factors.

Autor: Silke O; Department of Psychological Science, University of California, Irvine, Irvine, CA, United States. Electronic address: osilke@uci.edu., Simon SG; Department of Psychological Science, University of California, Irvine, Irvine, CA, United States., Sosnowski DW; Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States., Johnson SB; Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States; Department of Population Family and Reproductive Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States; Department of General Pediatrics, Johns Hopkins School of Medicine, Baltimore, MD, United States., Granger DA; Department of Psychological Science, University of California, Irvine, Irvine, CA, United States; Department of General Pediatrics, Johns Hopkins School of Medicine, Baltimore, MD, United States; Institute for Interdisciplinary Salivary Bioscience Research, University of California, Irvine, Irvine, CA, United States., Riis JL; Institute for Interdisciplinary Salivary Bioscience Research, University of California, Irvine, Irvine, CA, United States; Department of Health and Kinesiology, University of Illinois at Urbana-Champaign, Urbana, IL, United States.
Jazyk: angličtina
Zdroj: Psychoneuroendocrinology [Psychoneuroendocrinology] 2025 Jan; Vol. 171, pp. 107221. Date of Electronic Publication: 2024 Oct 20.
DOI: 10.1016/j.psyneuen.2024.107221
Abstrakt: Our understanding of associations between family-level risk factors and children's stress physiology is largely derived from studies that apply "mean-based" rather than "person-level" approaches. In this study, we employed group-based trajectory modeling, a person-centered approach, to identify children with similar patterns of stress-related sympathetic nervous system (SNS) and hypothalamic-pituitary-adrenal (HPA) axis activation, and explored associations between these patterns and maternal psychosocial risk. Participants were five-year-old children (N=147; 52 % female; 62 % Black/African American) and their mothers. Children's saliva was sampled four times during a series of emotional stressor tasks and later assayed for sAA and cortisol, indexing SNS and HPA activity, respectively. Mothers reported their depressive and anxiety symptoms, parenting stress, financial stress, and income. Results revealed two task-related patterns of change for sAA (Low-Stable vs. High-Increasing) and cortisol (Low-Stable vs. High-Decreasing) concentrations. Children from families with lower income were more likely to exhibit the High-Increasing SNS pattern, [OR=0.78, 95 % CI (0.64, 0.95)], and children of mothers reporting more anxiety symptoms [OR=1.06, 95 % CI (1.00, 1.12)] and more parenting stress [OR=1.04, 95 % CI (1.00, 1.07)] were more likely to show the High-Decreasing HPA pattern. Implications of this person-centered approach and findings for advancing our understanding of associations between family-level risk factors and children's stress physiology are discussed.
Competing Interests: Declaration of Competing Interest DAG is founder and chief scientific and strategy advisor at Salimetrics LLC and Salivabio LLC, and these relationships are managed by the policies of the committees on conflict of interest at the Johns Hopkins University School of Medicine and the University of California, Irvine. The other authors report no conflicts of interests.
(Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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