The prognostic significance of modified frailty index-5 in patients undergoing pneumonectomy for lung cancer.

Autor:	Sayan M; Department of Thoracic Surgery, Gazi University, Ankara, Turkey., Artiran B; Department of Thoracic Surgery, Gazi University, Ankara, Turkey., Ozturk F; Department of Thoracic Surgery, Gazi University, Ankara, Turkey., Fattahov M; Department of Thoracic Surgery, Gazi University, Ankara, Turkey., Akarsu I; Department of Thoracic Surgery, Gazi University, Ankara, Turkey., Aslan MT; Department of Thoracic Surgery, Gazi University, Ankara, Turkey., Ahmadova G; Department of Thoracic Surgery, Gazi University, Ankara, Turkey., Kurtoglu A; Department of Thoracic Surgery, Gazi University, Ankara, Turkey., Kurul IC; Department of Thoracic Surgery, Gazi University, Ankara, Turkey., Celik A; Department of Thoracic Surgery, Gazi University, Ankara, Turkey.
Jazyk:	angličtina
Zdroj:	Interdisciplinary cardiovascular and thoracic surgery [Interdiscip Cardiovasc Thorac Surg] 2024 Nov 06; Vol. 39 (5).
DOI:	10.1093/icvts/ivae179
Abstrakt:	Objectives: In some centrally located lung cancers, complete excision of the mass cannot be achieved with parenchymal-sparing procedures and pneumonectomy may be required. The mortality and morbidity rates of pneumonectomy were reported to be considerably high. Here, we investigated the effectivity of modified frailty index-5 (MFI-5) in patients undergoing pneumonectomy for non-small cell lung cancer. Methods: Data of patients who underwent pneumonectomy for non-small cell lung cancer between January 2018 and December 2023 were reviewed retrospectively. The MFI-5 score was determined by preoperative diabetes mellitus, hypertension, chronic obstructive pulmonary diseases, congestive heart failure and functional status. The effectiveness of the MFI-5 score for the presence of postoperative major complications and 30-day mortality was investigated by multivariate logistic regression analysis. A P-value <0.05 was considered statistically significant. Results: A total of 107 patients who met the inclusion criteria were included in the study. Eight (7.5%) of patients were female, and the mean age was 61.4 ± 8.7. The MFI-5 score was 0 in 48 patients (44.9%), 1 in 27 patients (25.2%) and 2 in 20 patients (18.7%). Postoperative 30-day mortality was detected in 4 patients (3.7%), and the major complications occurred in 42 patients (39.3%). In multivariate analysis, an MFI-5 score of 2 or higher (P = 0.008, OR: 4.9) was statistically significant for complications, whereas age, gender, side of the operation, <2 MFI-5 score, tumor diameter, type of surgery and lymph node metastasis status were not statistically significant (P > 0.05). Conclusions: The MFI-5 score is a significant indicator for predicting major postoperative events in patients who underwent pneumonectomy for non-small cell lung cancer. Clinical Registration Number: 2024-323, approved by Gazi University Local Ethics Committee. (© The Author(s) 2024. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery.)
Databáze:	MEDLINE
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