Real-world study and prognostic analysis of angioimmunoblastic T-cell lymphoma.

Autor:	Li S; Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.; Department of Oncology, Lymphoma Diagnosis and Treatment Center of Henan Province, Zhengzhou, Henan, China., Feng X; Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.; Department of Oncology, Lymphoma Diagnosis and Treatment Center of Henan Province, Zhengzhou, Henan, China., Song Y; Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.; Department of Oncology, Lymphoma Diagnosis and Treatment Center of Henan Province, Zhengzhou, Henan, China., Fan M; Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.; Department of Oncology, Lymphoma Diagnosis and Treatment Center of Henan Province, Zhengzhou, Henan, China., Chen Q; Department of Oncology, Xinxiang Medical College, Xinxiang, Henan, China.; Henan Academy of Innovations in Medical Science, Zhengzhou, Henan, China., Zhang M; Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.; Department of Oncology, Lymphoma Diagnosis and Treatment Center of Henan Province, Zhengzhou, Henan, China., Wu X; Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.; Department of Oncology, Lymphoma Diagnosis and Treatment Center of Henan Province, Zhengzhou, Henan, China., Dong M; Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.; Department of Oncology, Lymphoma Diagnosis and Treatment Center of Henan Province, Zhengzhou, Henan, China., Zhang J; Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.; Department of Oncology, Lymphoma Diagnosis and Treatment Center of Henan Province, Zhengzhou, Henan, China., Han L; Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.; Department of Oncology, Lymphoma Diagnosis and Treatment Center of Henan Province, Zhengzhou, Henan, China., Zhang X; Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.; Department of Oncology, Lymphoma Diagnosis and Treatment Center of Henan Province, Zhengzhou, Henan, China.
Jazyk:	angličtina
Zdroj:	Frontiers in immunology [Front Immunol] 2024 Oct 14; Vol. 15, pp. 1481301. Date of Electronic Publication: 2024 Oct 14 (Print Publication: 2024).
DOI:	10.3389/fimmu.2024.1481301
Abstrakt:	Objective: To analyze the clinical prognostic factors and treatments for angioimmunoblastic T-cell lymphoma (AITL) and develop a novel prognostic model specifically for AITL. Method: We retrospectively analyzed 231 patients with AITL from the First Affiliated Hospital of Zhengzhou University. Patients were enrolled between January 2014 and July 2023. The primary end points were overall survival (OS) and progression-free survival (PFS). Result: The patients' median age was 63 years, with 88.3% at an advanced stage (III/IV). The majority of patients (47.6%) received anthracycline-containing regimens, and there was no significant difference in survival compared with those treated with epigenetic-targeting and gemcitabine- containing regimens. The median PFS and OS were 6 and 17 months, respectively. In multivariate analysis, age >60 years, Eastern Cooperative Oncology Group performance status ≥2, elevated LDH, and splenomegaly were associated with inferior OS. Based on these four factors, a novel prognostic model (AITL model) was constructed that stratified patients into low-, intermediate-, and high-risk groups, with 2-year OS estimates of 63.6%, 42.1%, and 18.6%, respectively. Conclusion: Currently, there is no consensus on the optimal initial therapy for AITL, and the efficacy of anthracycline-containing regimens remains suboptimal. The novel model developed herein demonstrates predictive significance for both OS and PFS, and exhibits better stratification and discrimination capabilities. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 Li, Feng, Song, Fan, Chen, Zhang, Wu, Dong, Zhang, Han and Zhang.)
Databáze:	MEDLINE
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