Bibliometric and visualized analysis on global trends and hotspots of TAK1 in regulated cell death: 1999 to 2024.

Autor:	Huang K; Department of Human Anatomy and Neurobiology, School of Basic Medical Science, Central South University, Changsha, China.; Xiangya School of Medicine, Central South University, Changsha, China., He Y; Department of Human Anatomy and Neurobiology, School of Basic Medical Science, Central South University, Changsha, China.; Changsha Aier Eye Hospital, Changsha, China., Wan H; Department of Human Anatomy and Neurobiology, School of Basic Medical Science, Central South University, Changsha, China., Ban XX; Department of Human Anatomy and Neurobiology, School of Basic Medical Science, Central South University, Changsha, China., Chen XY; Department of Human Anatomy and Neurobiology, School of Basic Medical Science, Central South University, Changsha, China., Hu XM; Department of Human Anatomy and Neurobiology, School of Basic Medical Science, Central South University, Changsha, China., Wan XX; Department of Endocrinology, Third Xiangya Hospital, Central South University, Changsha, China., Lu R; Department of Molecular and Cellular Physiology, Stanford University, Stanford, CA, United States., Zhang Q; Department of Human Anatomy and Neurobiology, School of Basic Medical Science, Central South University, Changsha, China.; Department of Ophthalmology, Stanford University School of Medicine, Palo Alto, CA, United States.; Key Laboratory of Emergency and Trauma of Ministry of Education, College of Emergency and Trauma, Hainan Medical University, Haikou, China., Xiong K; Department of Human Anatomy and Neurobiology, School of Basic Medical Science, Central South University, Changsha, China.; Key Laboratory of Emergency and Trauma of Ministry of Education, College of Emergency and Trauma, Hainan Medical University, Haikou, China.; Hunan Key Laboratory of Ophthalmology, Changsha, China.
Jazyk:	angličtina
Zdroj:	Frontiers in immunology [Front Immunol] 2024 Oct 15; Vol. 15, pp. 1437570. Date of Electronic Publication: 2024 Oct 15 (Print Publication: 2024).
DOI:	10.3389/fimmu.2024.1437570
Abstrakt:	Background: Regulated cell death (RCD) is a genetically controlled form of cell death that plays an important role in organogenesis, tissue remodeling, and pathogenesis of cancers. Transforming growth factor-beta-activation kinase 1 (TAK1) is a member of the serine/threonine protein kinase family, which can respond to internal and external stimuli and participate in inflammatory responses through multiple signaling pathways and cellular processes. In the last two decades, the regulatory roles of TAK1 at the crossroads of multiple RCD pathways, including apoptosis, necroptosis, pyroptosis, and PANoptosis were revealed by 801 articles retrieved from the Web of Science Core Collection database. To analyze global research trends and hotspots concerning the role of TAK1 in RCD, the bibliometric and visualized analysis were applied in the current study. Methods: The data for this bibliometrics study were retrieved from the Web of Science Core Collection database. The search formula was (TS=(Apoptosis) OR TS=(pyroptosis) OR TS=(Necroptosis) OR TS=(PANoptosis) OR TS=(Autophagy) OR TS=(Ferroptosis) OR TS=(cuproptosis)) AND ((TS=(TAK1)) OR TS=(MAP3K7)). The co-occurrence and co-cited analysis on basic bibliometric parameters were conducted by VOSviewer. The dual-map overlay of journals, citation bursts, keyword timelines, and keyword bursts were analyzed by CiteSpace. Results: A total of 801 articles from 46 countries have been included in the analysis. The number of publications demonstrates a consistent increase from 1999 to 2024. The primary research institutions driving this field are Osaka University Notably, the Journal of Biological Chemistry stands out as the most popular journal in this domain. These publications collectively involve contributions from 4663 authors, with Jun Tsuji emerging as a prolific author. Jun Tsuji also gains the highest co-citation frequency. Emerging research hotspots are encapsulated by keywords, including apoptosis, NF-κB, inflammation, autophagy, and TNFα. Conclusion: This is the first bibliometric and visualized study to analyze the global trends and hotspots of TAK1 in RCD. Based on the analysis of 801 articles, the results provide a retrospective and comprehensive visualized view of the research hotspots and frontiers of TAK1 at the crossroads of multiple RCD signaling pathways and propose ideas for guiding their future investigations in molecular mechanisms and therapeutic strategies in this field. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The reviewer GY declared a shared affiliation, with no collaboration, with one of the authors, RL, to the handling editor at the time of the review. (Copyright © 2024 Huang, He, Wan, Ban, Chen, Hu, Wan, Lu, Zhang and Xiong.)
Databáze:	MEDLINE
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