Engineering Radiocatalytic Nanoliposomes with Hydrophobic Gold Nanoclusters for Radiotherapy Enhancement.

Autor: Carigga Gutierrez NM; Université Grenoble-Alpes, Inserm U1209, CNRS UMR 5309, Institute for Advanced Biosciences, Allée des Alpes, La Tronche, 38700, France., Clainche TL; Université Grenoble-Alpes, Inserm U1209, CNRS UMR 5309, Institute for Advanced Biosciences, Allée des Alpes, La Tronche, 38700, France., Bulin AL; Université Grenoble-Alpes, Inserm U1209, CNRS UMR 5309, Institute for Advanced Biosciences, Allée des Alpes, La Tronche, 38700, France., Leo S; Université Grenoble-Alpes, Inserm U1209, CNRS UMR 5309, Institute for Advanced Biosciences, Allée des Alpes, La Tronche, 38700, France.; Porphychem SAS, Longvic, 21600, France., Kadri M; Université Grenoble-Alpes, Inserm U1209, CNRS UMR 5309, Institute for Advanced Biosciences, Allée des Alpes, La Tronche, 38700, France., Abdelhamid AGA; Université Grenoble-Alpes, Inserm U1209, CNRS UMR 5309, Institute for Advanced Biosciences, Allée des Alpes, La Tronche, 38700, France., Pujol-Solé N; Université Grenoble-Alpes, Inserm U1209, CNRS UMR 5309, Institute for Advanced Biosciences, Allée des Alpes, La Tronche, 38700, France., Obaid G; Department of Bioengineering, University of Texas at Dallas, Richardson, TX, 75080, USA., Hograindleur MA; European Synchrotron Radiation Facility, CM01 Beamline, 71 Avenue des Martyrs, Grenoble, 38000, France., Gardette V; Université Lyon 1, Institut Lumière Matière, CNRS UMR 5306, Université de Lyon, Villeurbanne, France.; University Hospital of Grenoble Alpes, Grenoble, 38000, France., Busser B; Université Grenoble-Alpes, Inserm U1209, CNRS UMR 5309, Institute for Advanced Biosciences, Allée des Alpes, La Tronche, 38700, France.; University Hospital of Grenoble Alpes, Grenoble, 38000, France., Motto-Ros V; Université Lyon 1, Institut Lumière Matière, CNRS UMR 5306, Université de Lyon, Villeurbanne, France.; University Hospital of Grenoble Alpes, Grenoble, 38000, France., Josserand V; Université Grenoble-Alpes, Inserm U1209, CNRS UMR 5309, Institute for Advanced Biosciences, Allée des Alpes, La Tronche, 38700, France., Henry M; Université Grenoble-Alpes, Inserm U1209, CNRS UMR 5309, Institute for Advanced Biosciences, Allée des Alpes, La Tronche, 38700, France., Sancey L; Université Grenoble-Alpes, Inserm U1209, CNRS UMR 5309, Institute for Advanced Biosciences, Allée des Alpes, La Tronche, 38700, France., Hurbin A; Université Grenoble-Alpes, Inserm U1209, CNRS UMR 5309, Institute for Advanced Biosciences, Allée des Alpes, La Tronche, 38700, France., Elleaume H; Université de Grenoble-Alpes, Synchrotron Radiation for Biomedicine, Inserm UA07, 2280 Rue de la Piscine, Saint Martin d'Hères, 38400, France., Kandiah E; Department of Bioengineering, University of Texas at Dallas, Richardson, TX, 75080, USA., Guével XL; Université Grenoble-Alpes, Inserm U1209, CNRS UMR 5309, Institute for Advanced Biosciences, Allée des Alpes, La Tronche, 38700, France., Coll JL; Université Grenoble-Alpes, Inserm U1209, CNRS UMR 5309, Institute for Advanced Biosciences, Allée des Alpes, La Tronche, 38700, France., Broekgaarden M; Université Grenoble-Alpes, Inserm U1209, CNRS UMR 5309, Institute for Advanced Biosciences, Allée des Alpes, La Tronche, 38700, France.
Jazyk: angličtina
Zdroj: Advanced materials (Deerfield Beach, Fla.) [Adv Mater] 2024 Dec; Vol. 36 (50), pp. e2404605. Date of Electronic Publication: 2024 Oct 30.
DOI: 10.1002/adma.202404605
Abstrakt: Chemoradiation therapy is on the forefront of pancreatic cancer care, and there is a continued effort to improve its safety and efficacy. Liposomes are widely used to improve chemotherapy safety, and may accurately deliver high-Z element- radiocatalytic nanomaterials to cancer tissues. In this study, the interaction between X-rays and long-circulating nanoliposome formulations loaded with gold nanoclusters is explored in the context of oxaliplatin chemotherapy for desmoplastic pancreatic cancer. Hydrophobic gold nanoclusters stabilized with dodecanethiol (AuDDT) are efficiently incorporated in nanoliposomal bilayers. AuDDT-nanoliposomes significantly augmented radiation-induced • OH production, which is most effective with monochromatic X-rays at energies that exceed the K-shell electron binding energy of Au (81.7 keV). Cargo release assays reveal that AuDDT-nanoliposomes can permeabilize lipid bilayers in an X-ray dose- and formulation-dependent manner. The radiocatalytic effect of AuDDT-nanoliposomes significantly augments radiotherapy and oxaliplatin-chemoradiotherapy outcomes in 3D pancreatic microtumors. The PEGylated AuDDT-nanoliposomes display high tumor accumulation in an orthotopic mouse model of pancreatic cancer, showing promise for nanoliposomes as carriers for radiocatalytic nanomaterials. Altogether, compelling proof for chemo-radiation dose-enhancement using AuDDT-nanoliposomes is presented. Further improving the nanoliposomal loading of high-Z elements will advance the safety, efficacy, and translatability of such chemoradiation dose-enhancement approaches.
(© 2024 The Author(s). Advanced Materials published by Wiley‐VCH GmbH.)
Databáze: MEDLINE
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