A narrative review: exploring viral-induced malignancies through the lens of dysregulated cellular metabolism and glucose transporters.

Autor: Shahpar A; Gastroenterology and Hepatology Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran., Sofiani VH; Department of Microbiology, Golestan University of Medical Sciences, Gorgan, Iran., Nezhad NZ; Physiology Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran., Charostad M; Department of Biology, Faculty of Science, Yazd University, Yazd, Iran., Ghaderi R; Gastroenterology and Hepatology Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran., Farsiu N; Gastroenterology and Hepatology Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran., Kiskani AK; Clinical Research Development Unit, Afzalipour Hospital, Kerman University of Medical Sciences, Kerman, Iran., Pezeshki S; Endocrinology and Metabolism Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran., Nakhaie M; Gastroenterology and Hepatology Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran. mohsennakhaee1367@gmail.com.; Clinical Research Development Unit, Afzalipour Hospital, Kerman University of Medical Sciences, Kerman, Iran. mohsennakhaee1367@gmail.com.
Jazyk: angličtina
Zdroj: BMC cancer [BMC Cancer] 2024 Oct 29; Vol. 24 (1), pp. 1329. Date of Electronic Publication: 2024 Oct 29.
DOI: 10.1186/s12885-024-13013-y
Abstrakt: Introduction: In this narrative review, we unravel the complex interplay between oncogenic viruses, cellular metabolism, and glucose transporter (GLUT) dysregulation in viral-induced malignancies.
Methods: By explaining the diverse mechanisms through which seven major oncoviruses manipulate metabolic pathways and GLUT expression, particularly GLUT1, we provide novel insights into the critical role of metabolic reprogramming in viral replication and oncogenesis.
Results: Our exploration of the molecular pathways targeted by viral oncoproteins reveals a similarity between the metabolic alterations induced by viral infections and those observed in neoplastic transformation. A key finding of our review is the overexpression of GLUTs, particularly GLUT1, as a hallmark of both viral infections and many cancers.
Conclusions: By elucidating the complex interplay between viral oncoproteins, oncogene activation, tumor suppressor gene loss, and GLUT overexpression, we highlight the potential of GLUTs as novel targets for diagnosis, prognosis, and therapy of viral-induced malignancies.
(© 2024. The Author(s).)
Databáze: MEDLINE
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