Association between SMOFlipid and impaired brain development on term-equivalent age brain magnetic resonance imaging in very preterm infants.

Autor: Al-Mouqdad MM; Neonatal Intensive Care, Hospital of Pediatrics, King Saud Medical City, Al Imam Abdul Aziz Ibn Muhammad Ibn Saud, Riyadh, 12746, Saudi Arabia. m.almouqdad@ksmc.med.sa., Alshaikh B; Department of Pediatrics, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada., Sumaily HH; Neonatal Intensive Care, Hospital of Pediatrics, King Saud Medical City, Al Imam Abdul Aziz Ibn Muhammad Ibn Saud, Riyadh, 12746, Saudi Arabia., Alodhaidan NA; Neonatal Intensive Care, Hospital of Pediatrics, King Saud Medical City, Al Imam Abdul Aziz Ibn Muhammad Ibn Saud, Riyadh, 12746, Saudi Arabia., AlMahmoud L; Neonatal Intensive Care, Hospital of Pediatrics, King Saud Medical City, Al Imam Abdul Aziz Ibn Muhammad Ibn Saud, Riyadh, 12746, Saudi Arabia., Almotiri AA; Neonatal Intensive Care, Hospital of Pediatrics, King Saud Medical City, Al Imam Abdul Aziz Ibn Muhammad Ibn Saud, Riyadh, 12746, Saudi Arabia., Alkhourmi MA; Pediatric Gastroenterology Department, Hospital of Pediatrics, King Saud Medical City, Riyadh, Saudi Arabia., Abounassif MM; Radiology Department, Hospital of Pediatrics, King Saud Medical City, Riyadh, Saudi Arabia., Beh AF; Radiology Department, Hospital of Pediatrics, King Saud Medical City, Riyadh, Saudi Arabia., Alawad MA; General Pediatrics Department, Hospital of Pediatrics, King Saud Medical City, Riyadh, Saudi Arabia., Albraiki AA; Pharmacy Department, Pharmaceutical Care Services, King Saud Medical City, Riyadh, Saudi Arabia., Alqarni AA; Pharmacy Department, Pharmaceutical Care Services, King Saud Medical City, Riyadh, Saudi Arabia., Al-Anazi MR; Pharmacy Department, Pharmaceutical Care Services, King Saud Medical City, Riyadh, Saudi Arabia., Basodan NA; Pharmacy Department, Pharmaceutical Care Services, King Saud Medical City, Riyadh, Saudi Arabia., Assiri FM; Pharmacy Department, Pharmaceutical Care Services, King Saud Medical City, Riyadh, Saudi Arabia., Asfour SS; Clinical Pharmacy Department, Pharmaceutical Care Services, King Saud Medical City, Riyadh, Saudi Arabia.
Jazyk: angličtina
Zdroj: BMC pediatrics [BMC Pediatr] 2024 Oct 29; Vol. 24 (1), pp. 686. Date of Electronic Publication: 2024 Oct 29.
DOI: 10.1186/s12887-024-05153-8
Abstrakt: Soybean oil, medium-chain triglycerides, olive oil, and fish oil (SMOFlipid) is used without evidence of benefits. We investigated the relationship between lipid emulsions and brain injury in term-equivalent age magnetic resonance imaging (MRI) in 148 very preterm infants with a birth weight of < 1500 g at ≤ 32 gestational weeks in a neonatal intensive care unit. Infants who received soybean-based lipid emulsions between January 2015 and December 2018 were compared with those who received SMOFlipids between January 2019 and December 2022. A negative binomial generalized linear model was applied for bivariate analysis. Modified log-Poisson regression with generalized linear models and a robust variance estimator (Huber-White) were applied to adjust for potential confounders. The Kidokoro score was used to determine if lipid emulsion type would affect brain morphology and growth at term-equivalent age. Eighty-six (58.9%) received SMOFlipid. SMOFlipid was associated with lower focal signal abnormality, myelination delay, increased extracerebral space, and cerebellar volume reduction (P = 0.02, P = 0.007, P = 0.01, P = 0.02, respectively). SMOFlipidis are associated with brain insult, especially in white matter, cortical gray matter, and the cerebellum. Well-designed studies are needed to investigate the effect of lipid emulsions on the central nervous system.
(© 2024. The Author(s).)
Databáze: MEDLINE
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