Exceptional Bluetongue virus (BTV) and Epizootic hemorrhagic disease virus (EHDV) circulation in France in 2023.

Autor: Gondard M; ANSES/INRAE/ENVA-UPEC, UMR 1161 Virology, Laboratoire de santé animale, 14 rue Pierre et Marie Curie, 94700 Maisons-Alfort, France. Electronic address: mathilde.gondard@anses.fr., Postic L; ANSES/INRAE/ENVA-UPEC, UMR 1161 Virology, Laboratoire de santé animale, 14 rue Pierre et Marie Curie, 94700 Maisons-Alfort, France., Garin E; Groupements de Défense Sanitaire France, 37 rue de Lyon, 75012 Paris, France., Turpaud M; ANSES/INRAE/ENVA-UPEC, UMR 1161 Virology, Laboratoire de santé animale, 14 rue Pierre et Marie Curie, 94700 Maisons-Alfort, France., Vorimore F; Genomics Platform IdentyPath, Laboratory for Food Safety, ANSES, 94700 Maisons-Alfort, France., Ngwa-Mbot D; Groupements de Défense Sanitaire France, 37 rue de Lyon, 75012 Paris, France., Tran ML; Genomics Platform IdentyPath, Laboratory for Food Safety, ANSES, 94700 Maisons-Alfort, France., Hoffmann B; Friedrich-Loeffler-Institut, Institute of Diagnostic Virology, Südufer 10, 17493 Greifswald - Insel Riems., Warembourg C; Société Nationale des Groupements Techniques Vétérinaires, 5 rue Moufle, 75011 Paris, France., Savini G; Istituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise, Teramo, Italy., Lorusso A; Istituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise, Teramo, Italy., Marcacci M; Istituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise, Teramo, Italy., Felten A; Laboratory of Ploufragan, ANSES, Unit of Viral Genetics and Biosafety, Ploufragan, France., Roux AL; Laboratory of Ploufragan, ANSES, Unit of Viral Genetics and Biosafety, Ploufragan, France., Blanchard Y; Laboratory of Ploufragan, ANSES, Unit of Viral Genetics and Biosafety, Ploufragan, France., Zientara S; ANSES/INRAE/ENVA-UPEC, UMR 1161 Virology, Laboratoire de santé animale, 14 rue Pierre et Marie Curie, 94700 Maisons-Alfort, France., Vitour D; ANSES/INRAE/ENVA-UPEC, UMR 1161 Virology, Laboratoire de santé animale, 14 rue Pierre et Marie Curie, 94700 Maisons-Alfort, France., Sailleau C; ANSES/INRAE/ENVA-UPEC, UMR 1161 Virology, Laboratoire de santé animale, 14 rue Pierre et Marie Curie, 94700 Maisons-Alfort, France., Bréard E; ANSES/INRAE/ENVA-UPEC, UMR 1161 Virology, Laboratoire de santé animale, 14 rue Pierre et Marie Curie, 94700 Maisons-Alfort, France.
Jazyk: angličtina
Zdroj: Virus research [Virus Res] 2024 Nov 01; Vol. 350, pp. 199489. Date of Electronic Publication: 2024 Nov 01.
DOI: 10.1016/j.virusres.2024.199489
Abstrakt: Bluetongue (BT) and Epizootic Hemorrhagic Disease (EHD) are two notifiable animal diseases transmitted to ruminants by small hematophagous midges belonging to the Culicoides genus. The etiological agents, Bluetongue virus (BTV) and Epizootic hemorrhagic disease virus (EHDV), are both members of the Sedoreoviridae family and Orbivirus genus, which include double-stranded (ds) RNA segmented genomes (10 segments). By the end of the summer 2023, first's outbreaks of EHD were reported from the south west of France, concurrently with unexpectedly severe BT cases in Central France and Corsica. Within a few weeks, numerous BT and EHD outbreaks were recorded with significant sanitary and economic impact on cattle and sheep farms (no sanitary impact of EHD for sheep). Using a customized SISPA approach and the nanopore sequencing technology we successfully recovered genomic sequences from viral isolates and blood samples from infected animals from EHD and BT outbreaks. Three different viruses were responsible for these outbreaks: EHDV-8, BTV-8 and BTV-4. The EHDV-8 strain detected in France corresponded to the strain circulating in Tunisia, Sardinia and Spain since 2021 and 2022. A new BTV-8 strain of unknown origin, clearly different from the enzootic strain circulating in France since 2015, was responsible of the BT outbreaks in domestic ruminants in 2023 on both mainland France and Corsica. A second BTV, BTV-4, also involved in BT outbreaks in Corsica, corresponded to a BTV-4 strain occasionally detected on Corsica island since 2016, suggesting either a new introduction of this strain or a silent circulation on the field. The exceptional nature of orbivirus epizootics in France in 2023, including new introduction, emergence or incursions, raises numerous questions regarding BTV and EHDV dynamics and epidemiology and stresses out the need to identify factors involved in these emergences.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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