Biology, function and structure of the calcium homeostasis modulator family.

Autor: Polfer R; Cold Spring Harbor Laboratory, School of Biological Science at Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA., Furukawa H; Cold Spring Harbor Laboratory, School of Biological Science at Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.
Jazyk: angličtina
Zdroj: The Journal of physiology [J Physiol] 2024 Oct 29. Date of Electronic Publication: 2024 Oct 29.
DOI: 10.1113/JP285197
Abstrakt: Calcium homeostasis modulators (CALHMs) are the most recently discovered members of the large-pore channel family. They mediate the conductance of ions and larger molecules, such as ATP, and play critical roles in pathways related to Alzheimer's disease, neuroinflammation, neuromodulation, taste perception and innate immune responses. Since the inaugural report on CALHM1 in 2008, significant breakthroughs have revealed their biological roles, ion and ATP channel functions, and structures, positioning the field for further advancements. In this review, we discuss the overall progress and recent developments in understanding the biological roles, functions and molecular structures of CALHM proteins.
(© 2024 The Authors. The Journal of Physiology © 2024 The Physiological Society.)
Databáze: MEDLINE
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