Comparison of the diagnostic efficacy between imaging features and iodine density values for predicting microvascular invasion in hepatocellular carcinoma.

Autor:	Lv J; Department of Radiology, Nanxishan Hospital of Guangxi Zhuang Autonomous Region, Guilin, China., Li X; Department of Radiology, Nanxishan Hospital of Guangxi Zhuang Autonomous Region, Guilin, China., Mu R; Department of Radiology, Nanxishan Hospital of Guangxi Zhuang Autonomous Region, Guilin, China., Zheng W; Department of Radiology, Nanxishan Hospital of Guangxi Zhuang Autonomous Region, Guilin, China., Yang P; Department of Radiology, Nanxishan Hospital of Guangxi Zhuang Autonomous Region, Guilin, China., Huang B; Department of Radiology, Nanxishan Hospital of Guangxi Zhuang Autonomous Region, Guilin, China.; Graduate School, Guilin Medical University, Guilin, China., Liu F; Department of Radiology, Nanxishan Hospital of Guangxi Zhuang Autonomous Region, Guilin, China., Liu X; Philips (China) Investment Co., Ltd., Guangzhou Branch, Guangzhou, China., Song Z; Philips (China) Investment Co., Ltd., Guangzhou Branch, Guangzhou, China., Qin X; Department of Radiology, Nanxishan Hospital of Guangxi Zhuang Autonomous Region, Guilin, China., Zhu X; Department of Radiology, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, China.; Life Science and clinical Medicine Research Center, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, China.
Jazyk:	angličtina
Zdroj:	Frontiers in oncology [Front Oncol] 2024 Oct 14; Vol. 14, pp. 1437347. Date of Electronic Publication: 2024 Oct 14 (Print Publication: 2024).
DOI:	10.3389/fonc.2024.1437347
Abstrakt:	Background: In recent years, studies have confirmed the predictive capability of spectral computer tomography (CT) in determining microvascular invasion (MVI) in patients with hepatocellular carcinoma (HCC). Discrepancies in the predicted MVI values between conventional CT imaging features and spectral CT parameters necessitate additional validation. Methods: In this retrospective study, 105 cases of small HCC were reviewed, and participants were divided into MVI-negative (n=53, Male:48 (90.57%); mean age, 59.40 ± 11.79 years) and MVI-positive (n=52, Male:50(96.15%); mean age, 58.74 ± 9.21 years) groups using pathological results. Imaging features and iodine density (ID) obtained from three-phase enhancement spectral CT scans were gathered from all participants. The study evaluated differences in imaging features and ID values of HCC between two groups, assessing their diagnostic accuracy in predicting MVI occurrence in HCC patients. Furthermore, the diagnostic efficacy of imaging features and ID in predicting MVI was compared. Results: Significant differences were noted in the presence of mosaic architecture, nodule-in-nodule architecture, and corona enhancement between the groups, all with p-values < 0.001. There were also notable disparities in IDs between the two groups across the arterial phase, portal phase, and delayed phases, all with p-values < 0.001. The imaging features of nodule-in-nodule architecture, corona enhancement, and nonsmooth tumor margin demonstrate significant diagnostic efficacy, with area under the curve (AUC) of 0.761, 0.742, and 0.752, respectively. In spectral CT analysis, the arterial, portal, and delayed phase IDs exhibit remarkable diagnostic accuracy in detecting MVI, with AUCs of 0.821, 0.832, and 0.802, respectively. Furthermore, the combined models of imaging features, ID, and imaging features with ID reveal substantial predictive capabilities, with AUCs of 0.846, 0.872, and 0.904, respectively. DeLong test results indicated no statistically significant differences between imaging features and IDs. Conclusions: Substantial differences were noted in imaging features and ID between the MVI-negative and MVI-positive groups in this study. The ID and imaging features exhibited a robust diagnostic precision in predicting MVI. Additionally, our results suggest that both imaging features and ID showed similar predictive efficacy for MVI. Competing Interests: Authors XML and ZS are employed by Philips China Investment Co. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 Lv, Li, Mu, Zheng, Yang, Huang, Liu, Liu, Song, Qin and Zhu.)
Databáze:	MEDLINE
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