Immune therapeutic strategies for the senescent tumor microenvironment.

Autor: Yasuda T; Brown Center for Immunotherapy, Department of Medicine, Indiana University School of Medicine, Indianapolis, USA. tayasuda@iu.edu., Alan Wang Y; Brown Center for Immunotherapy, Department of Medicine, Indiana University School of Medicine, Indianapolis, USA.; Indiana University Melvin and Bren Simon Comprehensive Cancer Center Indianapolis, Indianapolis, USA.
Jazyk: angličtina
Zdroj: British journal of cancer [Br J Cancer] 2024 Oct 28. Date of Electronic Publication: 2024 Oct 28.
DOI: 10.1038/s41416-024-02865-7
Abstrakt: Senescent cells can either to promote immunosuppressive tumor microenvironment or facilitate immune surveillance. Despite the revolutionary impact of cancer immunotherapy, durable responses in solid tumors, particularly in advanced stages, remain limited. Recent studies have shed light on the influence of senescent status within the tumor microenvironment (TME) on therapy resistance and major efforts are needed to overcome these challenges. This review summarizes recent advancements in targeting cellular senescence, with a particular focus on immunomodulatory approaches on the hallmarks of cellular senescence.
(© 2024. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.)
Databáze: MEDLINE
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