Assembling a new generation of radiopharmaceuticals with supramolecular theranostics.

Autor: Moreno-Alcántar G; Department of Chemistry, School of Natural Sciences, Technical University of Munich, Garching bei München, Germany., Drexler M; Department of Chemistry, School of Natural Sciences, Technical University of Munich, Garching bei München, Germany., Casini A; Department of Chemistry, School of Natural Sciences, Technical University of Munich, Garching bei München, Germany. angela.casini@tum.de.; Munich Data Science Institute (MDSI), Technical University of Munich, Garching bei München, Germany. angela.casini@tum.de.
Jazyk: angličtina
Zdroj: Nature reviews. Chemistry [Nat Rev Chem] 2024 Dec; Vol. 8 (12), pp. 893-914. Date of Electronic Publication: 2024 Oct 28.
DOI: 10.1038/s41570-024-00657-4
Abstrakt: Supramolecular chemistry has been used to tackle some of the major challenges in modern science, including cancer therapy and diagnosis. Supramolecular platforms provide synthetic flexibility, rapid generation through self-assembly, facile labelling, unique topologies, tunable reversibility of the enabling noncovalent interactions, and opportunities for host-guest chemistry and mechanical bonding. In this Review, we summarize recent advances in the design and radiopharmaceutical application of discrete self-assembled coordination complexes and mechanically interlocked molecules - namely, metallacages and rotaxanes, respectively - as well as in situ-forming supramolecular aggregates, specifically pinpointing their potential as next-generation radiotheranostic agents. The outlook of such supramolecular constructs for potential applications in the clinic is discussed.
Competing Interests: Competing interests: The authors declare no competing interests.
(© 2024. Springer Nature Limited.)
Databáze: MEDLINE
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