A digital, decentralized trial of exercise therapy in patients with cancer.

Autor:	Underwood WP; Memorial Sloan Kettering Cancer Center (MSK), New York, NY, USA., Michalski MG; Memorial Sloan Kettering Cancer Center (MSK), New York, NY, USA., Lee CP; Memorial Sloan Kettering Cancer Center (MSK), New York, NY, USA., Fickera GA; Memorial Sloan Kettering Cancer Center (MSK), New York, NY, USA., Chun SS; Memorial Sloan Kettering Cancer Center (MSK), New York, NY, USA., Eng SE; Department of Human Genetics, University of California, Los Angeles, Los Angeles, CA, USA.; Institute for Precision Health, University of California, Los Angeles, Los Angeles, CA, USA.; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA, USA.; Department of Urology, University of California, Los Angeles, Los Angeles, CA, USA., Liu LY; Department of Human Genetics, University of California, Los Angeles, Los Angeles, CA, USA.; Institute for Precision Health, University of California, Los Angeles, Los Angeles, CA, USA.; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA, USA.; Department of Urology, University of California, Los Angeles, Los Angeles, CA, USA., Tsai BL; Department of Human Genetics, University of California, Los Angeles, Los Angeles, CA, USA.; Institute for Precision Health, University of California, Los Angeles, Los Angeles, CA, USA.; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA, USA.; Department of Urology, University of California, Los Angeles, Los Angeles, CA, USA., Moskowitz CS; Memorial Sloan Kettering Cancer Center (MSK), New York, NY, USA., Lavery JA; Memorial Sloan Kettering Cancer Center (MSK), New York, NY, USA., Van Zee KJ; Memorial Sloan Kettering Cancer Center (MSK), New York, NY, USA., Gardner GJ; Memorial Sloan Kettering Cancer Center (MSK), New York, NY, USA., Mueller JJ; Memorial Sloan Kettering Cancer Center (MSK), New York, NY, USA., Dang CT; Memorial Sloan Kettering Cancer Center (MSK), New York, NY, USA., Ehdaie B; Memorial Sloan Kettering Cancer Center (MSK), New York, NY, USA., Laudone VP; Memorial Sloan Kettering Cancer Center (MSK), New York, NY, USA., Eastham JA; Memorial Sloan Kettering Cancer Center (MSK), New York, NY, USA., Scott JM; Memorial Sloan Kettering Cancer Center (MSK), New York, NY, USA.; Weill Cornell Medical College, New York, NY, USA., Boutros PC; Department of Human Genetics, University of California, Los Angeles, Los Angeles, CA, USA.; Institute for Precision Health, University of California, Los Angeles, Los Angeles, CA, USA.; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA, USA.; Department of Urology, University of California, Los Angeles, Los Angeles, CA, USA., Jones LW; Memorial Sloan Kettering Cancer Center (MSK), New York, NY, USA. jonesl3@mskcc.org.; Weill Cornell Medical College, New York, NY, USA. jonesl3@mskcc.org.
Jazyk:	angličtina
Zdroj:	NPJ digital medicine [NPJ Digit Med] 2024 Oct 28; Vol. 7 (1), pp. 304. Date of Electronic Publication: 2024 Oct 28.
DOI:	10.1038/s41746-024-01288-1
Abstrakt:	We developed and evaluated the Digital Platform for Exercise (DPEx): a decentralized, patient-centric approach designed to enhance all aspects of clinical investigation of exercise therapy. DPEx integrated provision of a treadmill with telemedicine and remote biospecimen collection permitting all study procedures to be conducted in patient's homes. Linked health biodevices enabled high-resolution monitoring of lifestyle and physiological response. Here we describe the rationale and development of DPEx as well as feasibility evaluation in three different cohorts of patients with cancer: a phase 0a development study among three women with post-treatment primary breast cancer; a phase 0b proof-of-concept trial of neoadjuvant exercise therapy in 13 patients with untreated solid tumors; and a phase 1a level-finding trial of neoadjuvant exercise therapy in 53 men with localized prostate cancer. Collectively, our study demonstrates the utility of a fully digital, decentralized approach to conduct clinical trials of exercise therapy in a clinical population. (© 2024. The Author(s).)
Databáze:	MEDLINE
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