Development of a GAGG gamma camera for the imaging of prompt gammas during proton beam irradiation.

Autor: Yamamoto S; Faculty of Science and Engineering, Waseda University, Japan. Electronic address: s-yama@aoni.waseda.jp., Yamashita T; Kobe Proton Center, Japan., Kobashi Y; Kobe Proton Center, Japan., Yabe T; Takasaki Institute for Advanced Quantum Science, National Institutes for Quantum Science and Technology (QST), Japan., Nakanishi K; Nagoya University Graduate School of Medicine, Japan., Akagi T; Hyogo Ion Beam Medical Center, Japan., Yamaguchi M; Takasaki Institute for Advanced Quantum Science, National Institutes for Quantum Science and Technology (QST), Japan., Kawachi N; Takasaki Institute for Advanced Quantum Science, National Institutes for Quantum Science and Technology (QST), Japan., Kamada K; New Industry Creation Hatchery Center (NICHe), Tohoku University, Japan., Yoshikawa A; New Industry Creation Hatchery Center (NICHe), Tohoku University, Japan., Kataoka J; Faculty of Science and Engineering, Waseda University, Japan.
Jazyk: angličtina
Zdroj: Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB) [Phys Med] 2024 Nov; Vol. 127, pp. 104847. Date of Electronic Publication: 2024 Oct 28.
DOI: 10.1016/j.ejmp.2024.104847
Abstrakt: Prompt gammas imaging (PGI) is a promising method for observing a beam's shape and estimating the range of the beam from outside a subject. However 2-dimensional images of prompt gammas (PGs) during irradiation of protons were still difficult to measure. To achieve PGI, we developed a new gamma camera and imaged PGs while irradiating a phantom by proton beams. We also simultaneously measured prompt X-ray (PX) images with an X-ray camera from opposed direction and compared the images. The developed gamma camera uses a 10 mm thick GAGG block optically coupled to a flat panel photomultiplier tube (FP-PMT), and it is contained in a 20 mm thick tungsten container with a pinhole collimator attached. A poly-methyl-methacrylate (PMMA) block was irradiated by proton beams with total number of the protons similar to the clinical level, and the gamma camera imaged PGs and X-ray camera imaged PXs simultaneously. For all of the tested beams, we could measure the beam shapes of the PGs and the PXs and the ranges could also be estimated from the images. For both PG and PX images, time sequential images and accumulated images could be derived. We confirmed that the PGI using our developed gamma camera, as well as PXI, is promising for beam imaging and range estimation in proton therapy.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Associazione Italiana di Fisica Medica e Sanitaria. Published by Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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