Clinical Characteristics of Anti-synthetase Syndrome: Analysis From the Classification Criteria for Anti-Synthetase Syndrome Project.

Autor: Faghihi-Kashani S; University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., Yoshida A; Nippon Medical School Graduate School of Medicine, Tokyo, Japan., Bozan F; Hospital Clínico Universidad de Chile, Santiago, Chile., Zanframundo G; Università di Pavia and Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Pavia, Italy., Rozza D; Italian Society of Rheumatology, Milan, Italy., Loganathan A; Royal National Hospital for Rheumatic Diseases and University of Bath, Bath, UK, and Arthritis Australia, Broadway, Glebe, New South Wales, Australia., Dourado E; Centro Hospitalar do Baixo Vouga and Egas Moniz Health Alliance, Aveiro, and Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal., Sambataro G; Policlinico G. Rodolico-San Marco, University of Catania, Catania, Italy., Bauer-Ventura I; University of Chicago, Chicago, Illinois., Bae SS; David Geffen School of Medicine, University of California, Los Angeles, California., Lim D; Perelman School of Medicine & Corporal Michael J. Crescenz Department of Veterans Affairs Medical Center, Philadelphia, Pennsylvania., Rivero-Gallegos D; Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City, Mexico., Yamano Y; Tosei General Hospital, Seto, Japan., Selva-O'Callaghan A; Vall d'Hebron University Hospital, Universitat Autònoma de Barcelona, Barcelona, Spain., Mammen AL; National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, and Johns Hopkins University School of Medicine, Baltimore, Maryland., Scirè CA; University of Milano Bicocca, Milan, and Istituto di Ricovero e Cura a Carattere Scientifico San Gerardo dei Tintori Foundation, Monza, Italy., Montecucco C; Università di Pavia and Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Pavia, Italy., Oddis CV; University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., Fiorentino D; Stanford University School of Medicine, Redwood City, California., Bonella F; Ruhrlandklinik University Hospital, University of Duisburg-Essen, Essen, Germany., Miller FW; National Institute of Environmental Health Sciences, NIH, Durham, North Carolina., Lundberg IE; Karolinska Institutet, Stockholm, Sweden., Schmidt J; University Medical Center Göttingen, Göttingen, Germany, and Immanuel Klinik Rüdersdorf, University Hospital of the Brandenburg Medical School and Faculty of Health Sciences Brandenburg, Brandenburg Medical School Theodor Fontane, Rüdersdorf bei Berlin, Germany., Rojas-Serrano J; Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City, Mexico., Hudson M; McGill University, Montreal, Quebec, Canada., Kuwana M; Nippon Medical School Graduate School of Medicine, Tokyo, Japan., González-Gay MA; Instituto de Investigación Sanitaria-Fundación Jiménez Díaz, Madrid, and University of Cantabria, Santander, Spain., McHugh N; University of Bath, Bath, UK., Corte TJ; Royal Prince Alfred Hospital, University of Sydney, Sydney, New South Wales, Australia., Doyle TJ; Brigham and Women's Hospital, Boston, Massachusetts., Werth VP; Perelman School of Medicine & Corporal Michael J. Crescenz Department of Veterans Affairs Medical Center, Philadelphia, Pennsylvania., Gupta L; Royal Wolverhampton Hospitals NHS Trust, Wolverhampton, and The University of Manchester, Manchester, UK., Perez Roman DI; Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City, Mexico., Bianchessi LM; Università di Pavia, Pavia, Italy., Devarasetti PK; The University of Manchester, Manchester, UK., Shinjo SK; Faculdade de Medicina Faculdade de Medicina, Universidade de São Paulo, Universidade de Sao Paulo, Sao Paulo, Brazil., Luppi F; University of Milano Bicocca, Monza, Italy., Cavazzana I; University and Azienda Ospedaliera Spedali Civili, Brescia, Italy., Moghadam-Kia S; University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., Fornaro M; University of Bari, Bari, Italy., Volkmann ER; David Geffen School of Medicine, University of California, Los Angeles, California., Piga M; University of Cagliari and Azienda Ospedaliera Universitaria Cagliari, Cagliari, Italy., Loarce-Martos J; Hospital Universitario Ramón y Cajal, Madrid, Spain., De Luca G; Vita-Salute San Raffaele University & Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele Hospital, Milan, Italy., Knitza J; University Hospital of Giessen and Marburg, Philipps-University Marburg, Marburg, and Friedrich-Alexander-Universität Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany., Wolff-Cecchi V; Instituto Nacional del Torax and Universidad de Chile, Santiago, Chile., Sebastiani M; Guglielmo da Saliceto Hospital of Piacenza, University of Parma, Parma, Italy., Schiffenbauer A; National Institute of Environmental Health Sciences, NIH, Bethesda, Maryland., Rider LG; National Institute of Environmental Health Sciences, NIH, Bethesda, Maryland., Campanilho-Marques R; Faculdade de Medicina, Universidade de Lisboa and Centro Hospitalar Universitário Lisboa Norte, Lisbon, Portugal., Marts L; Emory University School of Medicine, Atlanta, Georgia., Bravi E; Ospedale Guglielmo da Saliceto, Piacenza, Italy., Gunawardena H; North Bristol NHS Trust, Bristol, UK., Aggarwal R; University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., Cavagna L; Università di Pavia and Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Pavia, Italy.
Jazyk: angličtina
Zdroj: Arthritis & rheumatology (Hoboken, N.J.) [Arthritis Rheumatol] 2024 Oct 28. Date of Electronic Publication: 2024 Oct 28.
DOI: 10.1002/art.43038
Abstrakt: Objective: Anti-synthetase syndrome (ASSD) is a rare systemic autoimmune rheumatic disease (SARD) with significant heterogeneity and no shared classification criteria. We aimed to identify clinical and serological features associated with ASSD that may be suitable for inclusion in the data-driven classification criteria for ASSD.
Methods: We used a large, international, multicenter "Classification Criteria for Anti-synthetase Syndrome" (CLASS) project database, which includes both patients with ASSD and controls with mimicking conditions, namely, SARDs and/or interstitial lung disease (ILD). The local diagnoses of ASSD and controls were confirmed by project team members. We employed univariable logistic regression and multivariable Ridge regression to evaluate clinical and serological features associated with an ASSD diagnosis in a randomly selected subset of the cohort.
Results: Our analysis included 948 patients with ASSD and 1,077 controls. Joint, muscle, lung, skin, and cardiac involvement were more prevalent in patients with ASSD than in controls. Specific variables associated with ASSD included arthritis, diffuse myalgia, muscle weakness, muscle enzyme elevation, ILD, mechanic's hands, secondary pulmonary hypertension due to ILD, Raynaud phenomenon, and unexplained fever. In terms of serological variables, Jo-1 and non-Jo-1 anti-synthetase autoantibodies, antinuclear antibodies with cytoplasmic pattern, and anti-Ro52 autoantibodies were associated with ASSD. In contrast, isolated arthralgia, dysphagia, electromyography/magnetic resonance imaging/muscle biopsy findings suggestive of myopathy, inflammatory rashes, myocarditis, and pulmonary arterial hypertension did not differentiate between patients with ASSD and controls or were inversely associated with ASSD.
Conclusion: We identified key clinical and serological variables associated with ASSD, which will help clinicians and offer insights into the development of data-driven classification criteria for ASSD.
(© 2024 The Author(s). Arthritis & Rheumatology published by Wiley Periodicals LLC on behalf of American College of Rheumatology. This article has been contributed to by U.S. Government employees and their work is in the public domain in the USA.)
Databáze: MEDLINE
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