Positive association between constipation and mild cognitive impairment in elders: A cross-sectional study.

Autor:	Huang KY; Department of Occupational and Environmental Health, School of Public Health, Guangxi Medical University, Nanning, Guangxi, China.; Guangxi Colleges and Universities Key Laboratory of Prevention and Control of Highly Prevalent Diseases, School of Public Health, Guangxi Medical University, Nanning, Guangxi, China.; Guangxi Key Laboratory of Environment and Health Research, School of Public Health, Guangxi Medical University, Nanning, Guangxi, China., Yu ZZ; Department of Toxicology, School of Public Health, Guangxi Medical University, Nanning, Guangxi, China., Tu JJ; Department of Toxicology, School of Public Health, Guangxi Medical University, Nanning, Guangxi, China., Tang XY; Guangxi Colleges and Universities Key Laboratory of Prevention and Control of Highly Prevalent Diseases, School of Public Health, Guangxi Medical University, Nanning, Guangxi, China.; Guangxi Key Laboratory of Environment and Health Research, School of Public Health, Guangxi Medical University, Nanning, Guangxi, China.; Department of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, Nanning, Guangxi, China., Huang JM; Educational Evaluation and Faculty Development Center, Guangxi Medical University, Nanning, Guangxi, China., Lu TM; Department of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, Nanning, Guangxi, China., Lu YQ; Department of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, Nanning, Guangxi, China., Huang MC; Department of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, Nanning, Guangxi, China., Zhou J; Department of Physiology, School of Basic Medical Sciences, Guangxi Medical University, Nanning, Guangxi, China., Maier AB; Department of Human Movement Sciences, @AgeAmsterdam, Amsterdam Movement Sciences, Faculty of Behavioural and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.; Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Centre for Healthy Longevity, National University Health System, Singapore., Ye KX; Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Centre for Healthy Longevity, National University Health System, Singapore., Yang Z; Department of Occupational and Environmental Health, School of Public Health, Guangxi Medical University, Nanning, Guangxi, China., Feng L; Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Centre for Healthy Longevity, National University Health System, Singapore.; Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Lu GD; Department of Toxicology, School of Public Health, Guangxi Medical University, Nanning, Guangxi, China.; School of the Public Health, Fudan University, Shanghai, China.
Jazyk:	angličtina
Zdroj:	Medicine [Medicine (Baltimore)] 2024 Oct 04; Vol. 103 (40), pp. e39943.
DOI:	10.1097/MD.0000000000039943
Abstrakt:	This study aimed to examine the association between constipation and mild cognitive impairment (MCI); and further elucidate the possible mechanisms involved. A cross-sectional study was conducted among community-dwelling elders (N = 789) in Nanning, China. Trained research staffs collected detailed information through questionnaires and physical examinations. A Bayesian network model was used to explore the hypothesized causal path. Synergistic effects of constipation with infrequent fruit consumption, inactive physical exercise, or history of stroke were observed in the risks of MCI occurrence. The Bayesian network model analyses showed 3 hypothesized causal-association paths leading to MCI occurrence. Among these, constipation, history of stroke, and years of schooling were directly related to the occurrence of MCI. Years of schooling indirectly affected MCI through infrequent fruit consumption and constipation; or through inactive physical exercises and history of stroke. This study demonstrates a direct association between constipation and increased risks of MCI. Competing Interests: The authors have no conflicts of interest to disclose. (Copyright © 2024 the Author(s). Published by Wolters Kluwer Health, Inc.)
Databáze:	MEDLINE
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