Current research status and clinical applications of noninvasive preimplantation genetic testing: A review.

Autor:	Yang S; Henan Key Laboratory of Fertility Protection and Aristogenesis, Luohe Central Hospital, Luohe, People's Republic of China.; Luohe Reproductive Medicine and Genetics Center, Luohe Central Hospital, Luohe, People's Republic of China., Xu B; Henan Key Laboratory of Fertility Protection and Aristogenesis, Luohe Central Hospital, Luohe, People's Republic of China.; Luohe Reproductive Medicine and Genetics Center, Luohe Central Hospital, Luohe, People's Republic of China., Zhuang Y; Henan Key Laboratory of Fertility Protection and Aristogenesis, Luohe Central Hospital, Luohe, People's Republic of China.; Luohe Reproductive Medicine and Genetics Center, Luohe Central Hospital, Luohe, People's Republic of China., Zhang Q; Henan Key Laboratory of Fertility Protection and Aristogenesis, Luohe Central Hospital, Luohe, People's Republic of China.; Luohe Reproductive Medicine and Genetics Center, Luohe Central Hospital, Luohe, People's Republic of China., Li J; Henan Key Laboratory of Fertility Protection and Aristogenesis, Luohe Central Hospital, Luohe, People's Republic of China.; Luohe Reproductive Medicine and Genetics Center, Luohe Central Hospital, Luohe, People's Republic of China., Fu X; Henan Key Laboratory of Fertility Protection and Aristogenesis, Luohe Central Hospital, Luohe, People's Republic of China.; Luohe Reproductive Medicine and Genetics Center, Luohe Central Hospital, Luohe, People's Republic of China.
Jazyk:	angličtina
Zdroj:	Medicine [Medicine (Baltimore)] 2024 Oct 04; Vol. 103 (40), pp. e39964.
DOI:	10.1097/MD.0000000000039964
Abstrakt:	Noninvasive preimplantation genetic testing (ni-PGT) is conducted by obtaining genetic information from embryos through the analysis of free DNA released by embryos in spent embryo culture medium or blastocoel fluid. Compared to conventional preimplantation genetic testing relying on trophectoderm biopsy, ni-PGT is characterized by its noninvasiveness. It has demonstrated early advancements in the detection of embryonic chromosomal aneuploidies and the diagnosis of monogenic diseases, showcasing considerable potential for clinical application. However, there are substantial controversies in the literature concerning the reliability of ni-PGT, the source of cell-free DNA, and maternal contamination. This paper elaborates on the principles, research advancements, effectiveness, and limitations of ni-PGT to provide a basis for clinical applications. Competing Interests: The authors have no conflicts of interest to disclose. (Copyright © 2024 the Author(s). Published by Wolters Kluwer Health, Inc.)
Databáze:	MEDLINE
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