Preclinical Evaluation of a Poly (Lactic Acid/Caprolactone) Bilayer Membrane and a Carbonate Apatite for Periodontal Regeneration: A Canine One-Wall Intrabony Defect Model.

Autor: Yamaki D; Department of Periodontology, Graduate School of Medical and Dental Science, Institute of Science Tokyo 1-5-45, Yushima, Bunkyo-Ku, Tokyo, Japan., Fukuba S; Department of Periodontology, Graduate School of Medical and Dental Science, Institute of Science Tokyo 1-5-45, Yushima, Bunkyo-Ku, Tokyo, Japan., Okada M; Department of Periodontology, Graduate School of Medical and Dental Science, Institute of Science Tokyo 1-5-45, Yushima, Bunkyo-Ku, Tokyo, Japan., Takeuchi S; Private Practice, Saitama, Japan., Hoshi S; Department of Periodontology, Graduate School of Medical and Dental Science, Institute of Science Tokyo 1-5-45, Yushima, Bunkyo-Ku, Tokyo, Japan.; Private Practice, Niigata, Japan., Schmidlin PR; Clinic of Conservative and Preventive Dentistry, Center of Dental Medicine, University of Zurich, Plattenstrasse 11, Zurich, Switzerland., Iwata T; Department of Periodontology, Graduate School of Medical and Dental Science, Institute of Science Tokyo 1-5-45, Yushima, Bunkyo-Ku, Tokyo, Japan.
Jazyk: angličtina
Zdroj: Journal of periodontal research [J Periodontal Res] 2024 Oct 28. Date of Electronic Publication: 2024 Oct 28.
DOI: 10.1111/jre.13355
Abstrakt: Aims: This preclinical study aimed to evaluate the periodontal tissue regenerative capacities of poly (lactic acid/caprolactone) (PLCL) bilayer membrane in one-wall intrabony defects in dogs. No study has assessed the efficacy of PLCL bilayer membrane for periodontal regeneration therapy despite the fact that PLCL bilayer membrane has proved efficient for bone regeneration.
Methods: In five beagle dogs, the bilateral mandibular second and fourth premolars were extracted 8 weeks before the experimental surgery. Standardized bone defects (5 mm in height and 6 mm in width) were surgically created on the mesial and distal roots of the bilateral third premolars in the mandible. The test groups were set up as follows: (i) carbonate apatite (CO 3 Ap) + PLCL, (ii) CO 3 Ap, (iii) xenograft (DBBM) + collagen membrane (CM), and (iv) DBBM. The control group was left empty. Radiological, histologic and histomorphometric characteristics were compared 8 weeks after surgery.
Results: No infectious complications were detected at any of the tested sites. The test groups exhibited a greater height and volume of the newly formed bone than the control group. They also showed a greater height of the newly formed cementum than the control group. However, the results were not statistically significant. The newly formed periodontal ligaments were inserted into newly formed bone and cementum in the test groups.
Conclusion: The combined use of PLCL bilayer membrane and CO 3 Ap demonstrated comparable performance for periodontal tissue regeneration in one-wall intrabony defects compared to conventional therapies.
(© 2024 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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