A New Platform Molecule from Gluconolactone? Access to Furanics, Rare Sugars, β-Ketoamides and Amino Furanones.

Autor: Jurys A; Department of Chemistry, University of Copenhagen, Universitetsparken 5, DK-2100, Copenhagen O, Denmark., Pedersen CM; Department of Chemistry, University of Copenhagen, Universitetsparken 5, DK-2100, Copenhagen O, Denmark.
Jazyk: angličtina
Zdroj: Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2024 Oct 28, pp. e202403453. Date of Electronic Publication: 2024 Oct 28.
DOI: 10.1002/chem.202403453
Abstrakt: Gluconolactone serves as a readily available and inexpensive starting material for synthesizing the potential platform chemical (Z)-3-deoxy-1,2 : 5,6-di-O-isopropylidene-D-erythro-hex-3-enolactone in two steps. In this work, the selective elimination of triacetone gluconolactone was optimized. The resulting product is a versatile molecule, capable of being transformed into various compound classes in one or a few steps, i. e. potentially a new biomass-based platform chemical. This study demonstrates how it can be transformed into furanics, rare sugars, β-ketoamides, and amino furanones.
(© 2024 The Author(s). Chemistry - A European Journal published by Wiley-VCH GmbH.)
Databáze: MEDLINE
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