Point-of-care breath sample analysis by semiconductor-based E-Nose technology discriminates non-infected subjects from SARS-CoV-2 pneumonia patients: a multi-analyst experiment.

Autor: Woehrle T; Department of Anesthesiology LMU University Hospital Ludwig Maximilian University Munich Germany., Pfeiffer F; Department of Anesthesiology LMU University Hospital Ludwig Maximilian University Munich Germany., Mandl MM; Institute for Medical Information Processing Biometry and Epidemiology Faculty of Medicine Ludwig Maximilian University Munich Germany.; Munich Center for Machine Learning Munich Germany., Sobtzick W; LANZ GmbH Bergisch Gladbach Germany., Heitzer J; Airbus Defence and Space GmbH Claude-Dornier-Straße Immenstaad Germany., Krstova A; Airbus Defence and Space GmbH Claude-Dornier-Straße Immenstaad Germany., Kamm L; Department of Anesthesiology LMU University Hospital Ludwig Maximilian University Munich Germany., Feuerecker M; Department of Anesthesiology LMU University Hospital Ludwig Maximilian University Munich Germany., Moser D; Department of Anesthesiology LMU University Hospital Ludwig Maximilian University Munich Germany., Klein M; Emergency Department LMU University Hospital Ludwig Maximilian University Munich Germany., Aulinger B; Department of Medicine II LMU University Hospital Ludwig Maximilian University Munich Germany., Dolch M; Department of Anesthesiology LMU University Hospital Ludwig Maximilian University Munich Germany.; Department of Anesthesiology Inn Klinikum Altötting Germany., Boulesteix AL; Institute for Medical Information Processing Biometry and Epidemiology Faculty of Medicine Ludwig Maximilian University Munich Germany.; Munich Center for Machine Learning Munich Germany., Lanz D; LANZ GmbH Bergisch Gladbach Germany., Choukér A; Department of Anesthesiology LMU University Hospital Ludwig Maximilian University Munich Germany.
Jazyk: angličtina
Zdroj: MedComm [MedComm (2020)] 2024 Oct 24; Vol. 5 (11), pp. e726. Date of Electronic Publication: 2024 Oct 24 (Print Publication: 2024).
DOI: 10.1002/mco2.726
Abstrakt: Metal oxide sensor-based electronic nose (E-Nose) technology provides an easy to use method for breath analysis by detection of volatile organic compound (VOC)-induced changes of electrical conductivity. Resulting signal patterns are then analyzed by machine learning (ML) algorithms. This study aimed to establish breath analysis by E-Nose technology as a diagnostic tool for severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) pneumonia within a multi-analyst experiment. Breath samples of 126 subjects with ( n  = 63) or without SARS-CoV-2 pneumonia ( n  = 63) were collected using the ReCIVA® Breath Sampler, enriched and stored on Tenax sorption tubes, and analyzed using an E-Nose unit with 10 sensors. ML approaches were applied by three independent data analyst teams and included a wide range of classifiers, hyperparameters, training modes, and subsets of training data. Within the multi-analyst experiment, all teams successfully classified individuals as infected or uninfected with an averaged area under the curve (AUC) larger than 90% and misclassification error lower than 19%, and identified the same sensor as most relevant to classification success. This new method using VOC enrichment and E-Nose analysis combined with ML can yield results similar to polymerase chain reaction (PCR) detection and superior to point-of-care (POC) antigen testing. Reducing the sensor set to the most relevant sensor may prove interesting for developing targeted POC testing.
Competing Interests: A.K. and J.H. are employees of Airbus Defense & Space, and authors W.S. and D.L. are part of Lanz GmbH, and have no potential relevant financial or non‐financial interests to disclose. The other authors have no conflicts of interest to declare.
(© 2024 The Author(s). MedComm published by Sichuan International Medical Exchange & Promotion Association (SCIMEA) and John Wiley & Sons Australia, Ltd.)
Databáze: MEDLINE
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