Cardiac troponin I release after transcatheter closure of atrial septal defects is associated with supraventricular arrhythmias on early follow-up.

Autor: Prochownik P; Department of Cardiac and Vascular Diseases, John Paul II Hospital, Institute of Cardiology, Krakow, Poland., Bielecka K; Department of Cardiac and Vascular Diseases, John Paul II Hospital, Institute of Cardiology, Krakow, Poland., Przewłocki T; Department of Cardiac and Vascular Diseases, John Paul II Hospital, Institute of Cardiology, Krakow, Poland., Sachajko Z; Faculty of Medicine, Jagiellonian University Medical College, Krakow, Poland., Gancarczyk U; Department of Cardiac and Vascular Diseases, John Paul II Hospital, Institute of Cardiology, Krakow, Poland., Wilkołek P; Department of Cardiac and Vascular Diseases, John Paul II Hospital, Institute of Cardiology, Krakow, Poland., Tworek M; Department of Cardiac and Vascular Diseases, John Paul II Hospital, Institute of Cardiology, Krakow, Poland., Podolec P; Department of Cardiac and Vascular Diseases, John Paul II Hospital, Institute of Cardiology, Krakow, Poland., Bielecka L; Faculty of Medicine, Jagiellonian University Medical College, Krakow, Poland., Komar M; Department of Cardiac and Vascular Diseases, John Paul II Hospital, Institute of Cardiology, Krakow, Poland.
Jazyk: angličtina
Zdroj: Postepy w kardiologii interwencyjnej = Advances in interventional cardiology [Postepy Kardiol Interwencyjnej] 2024 Sep; Vol. 20 (3), pp. 338-344. Date of Electronic Publication: 2024 Aug 14.
DOI: 10.5114/aic.2024.142326
Abstrakt: Introduction: Atrial septal defects (ASD) are prevalent congenital heart anomalies found in the adult population. Percutaneous ASD closure has become a routine clinical practice. Elevation of postprocedural transient cardiac biomarkers and exacerbation of supraventricular arrhythmias have been reported in the subject literature.
Aim: To explore the relationship between cardiac troponin I (cTnI) elevation and supraventricular ectopy (SVE) following percutaneous closure of secundum atrial septal defect (ASD) in adult patients.
Material and Methods: 600 consecutive patients who underwent successful transcatheter ASD secundum closure were analyzed. Serum levels of cTnI were measured before and within 72 h of device implantation. 24-hour Holter monitoring was performed before the procedure, at 1 month, and at 6 months of follow-up.
Results: SVE burden increased 1 month after the procedure (median 1021.00; min.-max. 11.00-29 862.00) compared to baseline values (median 146.00; min.-max. 0-1865.00; p < 0.01). 61.7% of patients demonstrated a cTnI rise exceeding 50% of the upper reference limit within 24 h of the procedure. A statistically significant positive correlation between SVE burden 1 month after the procedure and periprocedural cTnI increase ( p < 0.05, r = 0.41) was observed, while cTnI levels significantly correlated with procedure and fluoroscopy time ( p < 0.001), device size ( p < 0.001) and maximal ASD diameter ( p < 0.001).
Conclusions: A significant increase of cTnI is noted frequently after transcatheter ASD closure and seems to predict exacerbation in SVE burden on short-term follow up. The independent risk factors of cTnI rise are prolonged procedure duration and larger device sizes.
Competing Interests: The authors declare no conflict of interest.
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Databáze: MEDLINE