Investigating Mood and Cognition in People with Multiple Sclerosis: A Prospective Study Protocol.

Autor:	Cooper EC; Department of Psychiatry, University of Pennsylvania, Philadelphia, PA USA.; Penn Lifespan Informatics and Neuroimaging Center (PennLINC), Philadelphia, PA USA., Schindler MK; Department of Neurology, University of Pennsylvania, Philadelphia, PA USA.; Center for Neuroinflammation and Neurotherapeutics, University of Pennsylvania, Philadelphia, PA USA., Bar-Or A; Department of Neurology, University of Pennsylvania, Philadelphia, PA USA.; Center for Neuroinflammation and Neurotherapeutics, University of Pennsylvania, Philadelphia, PA USA., Brandstadter RB; Department of Neurology, University of Pennsylvania, Philadelphia, PA USA.; Center for Neuroinflammation and Neurotherapeutics, University of Pennsylvania, Philadelphia, PA USA., Calkins ME; Department of Psychiatry, University of Pennsylvania, Philadelphia, PA USA.; Lifespan Brain Institute, Penn Medicine and Children's Hospital of Philadelphia, Philadelphia, PA USA., Gur RC; Department of Psychiatry, University of Pennsylvania, Philadelphia, PA USA.; Lifespan Brain Institute, Penn Medicine and Children's Hospital of Philadelphia, Philadelphia, PA USA.; Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA USA., Jacobs DA; Department of Neurology, University of Pennsylvania, Philadelphia, PA USA.; Center for Neuroinflammation and Neurotherapeutics, University of Pennsylvania, Philadelphia, PA USA., Markowitz CE; Department of Neurology, University of Pennsylvania, Philadelphia, PA USA.; Center for Neuroinflammation and Neurotherapeutics, University of Pennsylvania, Philadelphia, PA USA., Moore TM; Department of Psychiatry, University of Pennsylvania, Philadelphia, PA USA.; Lifespan Brain Institute, Penn Medicine and Children's Hospital of Philadelphia, Philadelphia, PA USA., Naydovich LR; Department of Neurology, University of Pennsylvania, Philadelphia, PA USA.; Center for Neuroinflammation and Neurotherapeutics, University of Pennsylvania, Philadelphia, PA USA., Perrone CM; Department of Neurology, University of Pennsylvania, Philadelphia, PA USA.; Center for Neuroinflammation and Neurotherapeutics, University of Pennsylvania, Philadelphia, PA USA., Ruparel K; Department of Psychiatry, University of Pennsylvania, Philadelphia, PA USA., Spangler BC; Penn Statistics in Imaging and Visualization Center (PennSIVE), Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, PA USA., Troyan S; Department of Psychiatry, University of Pennsylvania, Philadelphia, PA USA., Shinohara RT; Penn Statistics in Imaging and Visualization Center (PennSIVE), Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, PA USA.; Department of Information Services, University of Pennsylvania, Philadelphia, PA USA., Satterthwaite TD; Department of Psychiatry, University of Pennsylvania, Philadelphia, PA USA.; Penn Lifespan Informatics and Neuroimaging Center (PennLINC), Philadelphia, PA USA.; Department of Information Services, University of Pennsylvania, Philadelphia, PA USA., Baller EB; Department of Psychiatry, University of Pennsylvania, Philadelphia, PA USA.; Penn Lifespan Informatics and Neuroimaging Center (PennLINC), Philadelphia, PA USA.
Jazyk:	angličtina
Zdroj:	MedRxiv : the preprint server for health sciences [medRxiv] 2024 Oct 04. Date of Electronic Publication: 2024 Oct 04.
DOI:	10.1101/2024.10.02.24314787
Abstrakt:	Multiple sclerosis (MS) is an immune-mediated neurological disorder that affects one million people in the United States. Up to 50% of people with MS experience depression, yet the mechanisms of depression in MS remain under-investigated. Studies of medically healthy participants with depression have described associations between white matter variability and depressive symptoms, but frequently exclude participants with medical comorbidities and thus cannot be extrapolated to people with intracranial diseases. White matter lesions are a key pathologic feature of MS and could disrupt pathways involved in depression symptoms. The purpose of this study is to investigate the impact of brain network disruption on depression using MS as a model. We will obtain structured clinical and cognitive assessments from two hundred fifty participants with MS and prospectively evaluate white matter lesion burden as a predictor of depressive symptoms. Ethics approval was obtained from The University of Pennsylvania Institutional Review Board (Protocol #853883). The results of this study will be presented at scientific meetings and conferences and published in peer-reviewed journals. Competing Interests: COMPETING INTEREST STATEMENTS The authors declare no competing interests.
Databáze:	MEDLINE
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