Intrinsic dynamic shapes responses to external stimulation in the human brain.

Autor:	Nentwich M; The Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, USA., Leszczynski M; Departments of Psychiatry and Neurology, Columbia University College of Physicians and Surgeons, New York, NY, USA.; Translational Neuroscience Lab Division, Center for Biomedical Imaging and Neuromodulation, Nathan Kline Institute, Orangeburg, NY, USA.; Cognitive Science Department, Institute of Philosophy, Jagiellonian University, Kraków, Poland., Schroeder CE; Departments of Psychiatry and Neurology, Columbia University College of Physicians and Surgeons, New York, NY, USA.; Translational Neuroscience Lab Division, Center for Biomedical Imaging and Neuromodulation, Nathan Kline Institute, Orangeburg, NY, USA., Bickel S; The Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, USA.; Departments of Neurology and Neurosurgery, Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY, USA.; Center for Biomedical Imaging and Neuromodulation, Nathan Kline Institute, Orangeburg, NY, USA., Parra LC; Department of Biomedical Engineering, The City College of New York, New York, NY, USA.
Jazyk:	angličtina
Zdroj:	BioRxiv : the preprint server for biology [bioRxiv] 2024 Oct 18. Date of Electronic Publication: 2024 Oct 18.
DOI:	10.1101/2024.08.05.606665
Abstrakt:	Sensory stimulation of the brain reverberates in its recurrent neuronal networks. However, current computational models of brain activity do not separate immediate sensory responses from intrinsic recurrent dynamics. We apply a vector-autoregressive model with external input (VARX), combining the concepts of "functional connectivity" and "encoding models", to intracranial recordings in humans. We find that the recurrent connectivity during rest is largely unaltered during movie watching. The intrinsic recurrent dynamic enhances and prolongs the neural responses to scene cuts, eye movements, and sounds. Failing to account for these exogenous inputs, leads to spurious connections in the intrinsic "connectivity". The model shows that an external stimulus can reduce intrinsic noise. It also shows that sensory areas have mostly outward, whereas higher-order brain areas mostly incoming connections. We conclude that the response to an external audiovisual stimulus can largely be attributed to the intrinsic dynamic of the brain, already observed during rest. Competing Interests: Declaration of interests The authors declare no competing interests.
Databáze:	MEDLINE
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