| Autor: |
Vecchiarelli HA, Bisht K, Sharma K, Weiser Novak S, Traetta ME, Garcia-Segura ME, St-Pierre MK, Savage JC, Willis C, Picard K, Bordeleau M, Vernoux N, Khakpour M, Garg R, Loewen SM, Murray CJ, Grinberg YY, Faustino J, Halvorson T, Lau V, Pluchino S, Vexler ZS, Carson MJ, Manor U, Peruzzotti-Jametti L, Tremblay MÈ |
| Jazyk: |
angličtina |
| Zdroj: |
BioRxiv : the preprint server for biology [bioRxiv] 2024 Oct 18. Date of Electronic Publication: 2024 Oct 18. |
| DOI: |
10.1101/2024.10.15.618087 |
| Abstrakt: |
This study examined dark microglia-a state linked to central nervous system pathology and neurodegeneration-during postnatal development in the mouse ventral hippocampus, finding that dark microglia interact with blood vessels and synapses and perform trogocytosis of pre-synaptic axon terminals. Furthermore, we found that dark microglia in development notably expressed C-type lectin domain family 7 member A (CLEC7a), lipoprotein lipase (LPL) and triggering receptor expressed on myeloid cells 2 (TREM2) and required TREM2, differently from other microglia, suggesting a link between their role in remodeling during development and central nervous system pathology. Together, these results point towards a previously under-appreciated role for dark microglia in synaptic pruning and plasticity during normal postnatal development. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
