Anti-proliferative Activity of Vitex negundo Leaf Extracts on PA1 Human Ovarian Cancer Cell Lines.
| Autor: | Shettar PS; Department of Biotechnology and Microbiology, Karnatak University, Dharwad- 580003. Karnataka, India., Hiremath MB; Department of Biotechnology and Microbiology, Karnatak University, Dharwad- 580003. Karnataka, India., Kumbar VM; Basic Science Research Centre, KLE Academy of Higher Education and Research (KLE University), Belagavi, Karnataka, India. |
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| Jazyk: | angličtina |
| Zdroj: | Archives of Razi Institute [Arch Razi Inst] 2024 Apr 30; Vol. 79 (2), pp. 426-436. Date of Electronic Publication: 2024 Apr 30 (Print Publication: 2024). |
| DOI: | 10.32592/ARI.2024.79.2.426 |
| Abstrakt: | In Ayurveda, Vitex negundo (VN) is used as a drug to manage pain, inflammation, and problems related to polycystic ovary disease and the menstrual cycle. The bioactive compounds isolated from this plant exhibit anti-inflammatory, anti-oxidant, anti-cancer, and microbicidal properties. The shrub VN is known for its role in the modulation of cellular events like apoptosis and cell cycle. There is still a scarcity of data in the literature on the cytotoxic activity of VN extracts on ovarian cancer. Therefore, in the present study, the phytochemical composition, anti-oxidant, and anti-cancer activities of leaf extracts were evaluated. The chloroform and methanol fractions exhibited higher phenolic content (161.04 ± 0.02 mg/g GAE and 152.56 ± 0.05 mg/g GAE, respectively) than those of other fractions. The aqueous and petroleum ether fractions exhibited higher flavonoid content (215.27 ± 0.28 mg/g QE and 111.82 ± 0.05 mg/g QE, respectively). The acetone and methanol extracts showed significant anti-oxidant capacities. Both leaf extracts of VN inhibited PA1 cancer cell growth in a dose-dependent manner with IC Competing Interests: No potential conflict of interest was reported by the author(s). |
| Databáze: | MEDLINE |
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