[Study participation in clozapine-resistant psychosis: a case study on decision-making capacity].

Autor:	den Toom M, Zantvoord JB, Sutterland AL, Luykx JJ, Blanken LME, Aarts R, de Koning MB
Jazyk:	Dutch; Flemish
Zdroj:	Tijdschrift voor psychiatrie [Tijdschr Psychiatr] 2024; Vol. 66 (8), pp. 443-446.
Abstrakt:	Informed consent is a requirement for medical research. Obtaining consent can be complex in patients with severe psychiatric disorders, often leading to their exclusion from study participation. Here, we discuss a case involving a patient with clozapine-resistant schizophrenia, highlighting the different perspectives of caregivers and physician-researchers, with an emphasis on decision-making capacity. The case illustrates the complexity of informed consent in this population, including the challenges in assessing decision-making capacity, ethical dilemmas, and potential improvements. We conclude that improving existing standardized assessment tools, promoting inclusive approaches to research participation, and supporting patient representation in decision-making processes can contribute to the quality and integrity of medical research involving individuals with the most severe forms of psychiatric disorders.
Databáze:	MEDLINE
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