Concurrent Oral Squamous Cell Carcinoma and Bisphosphonate-Related Osteonecrosis of the Maxilla: A Case Report and Literature Review.

Autor: Yoon M; Thyroid, Head and Neck Cancer (THANC) Foundation, New York, New York, USA.; Department of Otolaryngology-Head and Neck Surgery, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Ramirez R; Department of Otolaryngology-Head and Neck Surgery, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Yun J; Thyroid, Head and Neck Cancer (THANC) Foundation, New York, New York, USA.; Department of Otolaryngology-Head and Neck Surgery, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Wiedmer C; Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Brandwein-Weber M; Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Khorsandi AS; Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Buchbinder D; Department of Otolaryngology-Head and Neck Surgery, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Icahn School of Medicine at Mount Sinai, New York, New York, USA., Khan MN; Department of Otolaryngology-Head and Neck Surgery, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Jazyk: angličtina
Zdroj: Head & neck [Head Neck] 2025 Jan; Vol. 47 (1), pp. E1-E10. Date of Electronic Publication: 2024 Oct 28.
DOI: 10.1002/hed.27974
Abstrakt: Introduction: Bisphosphonates (BPs) are widely used for osteoporosis and cancer-induced bone diseases due to their antiresorptive properties, yet they pose risks such as medication-related osteonecrosis of the jaw (MRONJ).
Methods: We present a unique case of concurrent oral squamous cell carcinoma (SCC) and MRONJ in a 72-year-old female chronically treated with oral ibandronate for osteoporosis. Following a dental extraction, she developed a nonhealing wound in the maxilla. Following conservative treatment, the patient underwent a maxillectomy and extensive tissue reconstructions to control her infection and address suspicions of an underlying malignancy.
Results: Histopathological examinations confirmed simultaneous osteonecrosis and well-differentiated SCC in the maxillary sinus and surrounding tissues. Despite multiple surgeries, the patient's disease progressed rapidly. Upon examining the literature for patients with a history of BP use diagnosed with MRONJ and/or SCC, a total of 16 cases report a diagnostic dilemma between MRONJ and locoregional SCC. Three of the 16 cases report a final diagnosis of concurrent MRONJ and SCC. This report is the fourth reported case of concurrency to date.
Conclusions: The patient's complex clinical course underscores the diagnostic challenges and therapeutic dilemmas in managing concurrent MRONJ and SCC, highlighting the need for vigilant monitoring and interdisciplinary collaboration in similar cases.
(© 2024 Wiley Periodicals LLC.)
Databáze: MEDLINE
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