A decrease in serum dihydrotestosterone levels in 9-year-old Vietnamese children from a dioxin exposure area.

Autor:	Nguyen OTP; School of Preventive Medicine and Public Health, Hanoi Medical University., Honma S; Faculty of Health Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University., Hoang PD; Hanoi Department of Health., Van Nguyen K; University of Medicine and Pharmacy, Vietnam National University., Le AT; IDEA Consultants, Inc., Nakayama SF; Centre for Health and Environmental Risk Research, National Institute., Ho MD; Lac Hong University., Nguyen VH; Hanoi Medical University., Van Dao T; Hai Phong Medical College., Dang ND; University of Medicine and Pharmacy, Vietnam National University., Ngo TTM; Hanoi Medical University., Van Pham T; Hanoi Medical University., Van Ngo T; School of Preventive Medicine and Public Health, Hanoi Medical University., Van Vo C; Phu Cat Health Centre., Nakagawa H; Kanazawa Medical University., Kido T; Faculty of Health Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University.
Jazyk:	angličtina
Zdroj:	Environmental health and preventive medicine [Environ Health Prev Med] 2024; Vol. 29, pp. 58.
DOI:	10.1265/ehpm.24-00190
Abstrakt:	Background: Dioxin is an environmental pollutant as well as an endocrine disruptor in humans. Our longitudinal study wants to clarify the relationship between dioxin exposure and endocrine disorders in children living in the Vietnamese dioxin hotspot. Method: Seventeen congeners of polychlorinated dibenzo-p-dioxins/polychlorinated dibenzo-furans (PCDDs/PCDFs) in maternal breast milk and seven serum steroid hormones in children of 43 and 46 mothers and their 9-year-old children from the non-exposure and the hotspot areas were measured, respectively. The steroid metabolic enzyme ratios were calculated based on the hormone level ratio. Results: Most dioxin/furan congeners and toxic equivalents (TEQs) levels were significantly higher in the hotspot than in the non-exposure area, except for 2,4,7,8-TeCDF. The height and weight of girls from the hotspot area were substantially lower and inversely correlated with dioxin congener levels/total TEQs level dioxin. The dihydrotestosterone (DHT) levels in the hotspot were markedly lower than those in non-exposed in both genders. The cortisol concentrations were significantly higher in the hotspot than those from the non-exposure area only in the girls. The DHT/testosterone ratios that exhibited the 5α- or 5β-reductase activity declined by 50% in the hotspot area for both genders. The DHT levels showed strong inverse correlations with almost the PCDDs/PCDFs congeners and total TEQs dioxin in breast milk. Conclusions: This finding suggests that dioxin exposure in maternal breast milk might impact children's endocrine system until 9 years old, especially on the DHT biosynthesis.
Databáze:	MEDLINE
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