The association between aberrant salience and psychotic experiences in general population twins, and genetic vulnerability as a modifier.

Autor: Drukker M; Department of Psychiatry and Neuropsychology, School of Mental Health and Neuroscience (MHeNS), Maastricht University Medical Centre, Maastricht, the Netherlands. Marjan.Drukker@MaastrichtUniversity.nl., Todor T; Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands., Bongaarts J; Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands., Broggi E; Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands., Kelkar M; Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands., Wigglesworth T; Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands., Verhiel K; Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands., van Leeuwen K; Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands., Koster M; Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands., Derom C; Department of Obstetrics and Gynecology, Ghent University Hospitals, Ghent University, Ghent, Belgium., Thiery E; Department of Neurology, Ghent University Hospital, Ghent University, Ghent, Belgium., De Hert M; University Psychiatric Centre, Katholieke Universiteit Leuven, Kortenberg, Belgium.; Department of Neurosciences, Centre for Clinical Psychiatry, Katholieke Universiteit Leuven, Louvain, Belgium.; Leuven Brain Institute, Katholieke Universiteit Leuven, Louvain, Belgium.; Antwerp Health, Law and Ethic Chair, University of Antwerp, Antwerp, Belgium., Menne-Lothmann C; Department of Psychiatry and Neuropsychology, School of Mental Health and Neuroscience (MHeNS), Maastricht University Medical Centre, Maastricht, the Netherlands., Decoster J; Psychiatric Care Sint-Kamillus, Brothers of Charity, Bierbeek, Belgium., Collip D; Department of Psychiatry and Neuropsychology, School of Mental Health and Neuroscience (MHeNS), Maastricht University Medical Centre, Maastricht, the Netherlands., van Winkel R; Department of Psychiatry and Neuropsychology, School of Mental Health and Neuroscience (MHeNS), Maastricht University Medical Centre, Maastricht, the Netherlands.; Department of Neurosciences, Research Group Psychiatry, Center for Clinical Psychiatry, Katholieke Universiteit Leuven, Louvain, Belgium.; University Psychiatric Center, Katholieke Universiteit Leuven, Leuven, Belgium., Jacobs N; Department of Psychiatry and Neuropsychology, School of Mental Health and Neuroscience (MHeNS), Maastricht University Medical Centre, Maastricht, the Netherlands.; Faculty of Psychology, Open Universiteit, Heerlen, The Netherlands., Guloksuz S; Department of Psychiatry and Neuropsychology, School of Mental Health and Neuroscience (MHeNS), Maastricht University Medical Centre, Maastricht, the Netherlands.; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA., Rutten B; Department of Psychiatry and Neuropsychology, School of Mental Health and Neuroscience (MHeNS), Maastricht University Medical Centre, Maastricht, the Netherlands., van Os J; Department of Psychiatry and Neuropsychology, School of Mental Health and Neuroscience (MHeNS), Maastricht University Medical Centre, Maastricht, the Netherlands.; Department of Psychiatry, Brain Centre Rudolf Magnus, University Medical Centre Utrecht, Utrecht, The Netherlands.; Department of Psychosis Studies, Institute of Psychiatry, King's College London, King's Health Partners, London, UK.
Jazyk: angličtina
Zdroj: BMC psychiatry [BMC Psychiatry] 2024 Oct 26; Vol. 24 (1), pp. 736. Date of Electronic Publication: 2024 Oct 26.
DOI: 10.1186/s12888-024-06176-2
Abstrakt: Background: Previous studies assessing the hypothesis that the construct of 'aberrant salience' is associated with psychosis and psychotic symptoms showed conflicting results. For this reason, the association between measures to index aberrant salience and subclinical psychotic symptoms in a general population sample was analysed. In addition, genetic vulnerability was added to the analysis as a modifier to test the hypothesis that modification by genetic vulnerability may explain variability in the results.
Methods: The TwinssCan project obtained data from general population twins (N = 887). CAPE (Community Assessment of Psychic Experience) scores were used to index psychotic experiences. Aberrant salience was assessed with white noise task and ambiguous situations task.
Results: Measures of aberrant salience were not associated with psychotic experiences, nor was there evidence for an interaction with genetic predisposition in this association (Z = 1.08, p = 0.282).
Conclusions: Various studies including the present could not replicate the association between aberrant salience and psychotic experiences in general population samples. The conflicting findings might be explained by moderation by genetic vulnerability, but results are inconsistent. If there was evidence for a main effect or interaction, this was in the positive symptom scale only. On the other hand, the association was more robust in so-called 'ultra-high risk' patients and first episode psychosis patients. Thus, this association may represent a state-dependent association, present only at the more severe end of the psychosis spectrum.
(© 2024. The Author(s).)
Databáze: MEDLINE
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