Hemodynamic monitoring during weaning from mechanical ventilation in critically ill pediatric patients: a prospective observational study.

Autor: Abdelgawad TA; Department of Pediatric Intensive Care Unit, Faculty of Medicine, Ain Shams University, Cairo, Egypt., Ibrahim HM; Department of Pediatric Intensive Care Unit, Faculty of Medicine, Ain Shams University, Cairo, Egypt., Elsayed EM; Department of Pediatric Cardiology Unit, Faculty of Medicine, Ain Shams University, Cairo, Egypt., Abdelhamid NS; Department of Pediatric Intensive Care Unit, Faculty of Medicine, Ain Shams University, Cairo, Egypt. nehad.salah@med.asu.edu.eg., Bawady SAH; Department of Clinical Pathology, Faculty of Medicine, Ain Shams University, Cairo, Egypt., Rezk AR; Department of Pediatric Intensive Care Unit, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Jazyk: angličtina
Zdroj: BMC pediatrics [BMC Pediatr] 2024 Oct 26; Vol. 24 (1), pp. 681. Date of Electronic Publication: 2024 Oct 26.
DOI: 10.1186/s12887-024-05110-5
Abstrakt: Background: Cardiovascular dysfunction is a significant factor contributing to weaning failure in mechanically ventilated children. Understanding the cardiopulmonary pathophysiological changes that occur during weaning is a prerequisite for the early recognition of weaning failure of cardiovascular origin. This study aimed to assess the effect of weaning trials on central hemodynamics and to identify the indices predictive of cardiac-related weaning failure.
Methods: This prospective observational study was conducted in the Pediatric Intensive Care Unit (PICU) and included mechanically ventilated patients aged between 2 and 30 months who were on minimal ventilatory settings and ready for weaning. Patients who were hemodynamically unstable, diagnosed with neuromuscular diseases, or diagnosed with cardiac diseases were excluded. Hemodynamic parameters were evaluated during weaning from ventilation via echocardiography and noninvasive cardiometry during pressure support (PS) ventilation and at the end of the spontaneous breathing trial (SBT).
Results: The study included 50 patients, comprising 30 males (60%) and 20 females (40%) with ages ranging from 2 to 30 months. Echocardiography revealed a significant increase in the cardiac index (CI), tricuspid annular plane systolic excursion (TAPSE), and the E/A ratio at the end of SBT. Moreover, right ventricular systolic pressure (RVSP) significantly decreased. Noninvasive cardiometry revealed a significant increase in the index of contractility (ICON) and CI at the end of SBT (p-value = 0.023 and < 0.001, respectively). Of the 12 (25%) patients who failed their first extubation trial, they exhibited a significantly lower CI and TAPSE (p values = 0.001 and 0.001, respectively).
Conclusion: This study identified that weaning from mechanical ventilation in children is associated with hemodynamic changes, which can impact weaning success and reveal potential ventricular dysfunction. Bedside echocardiography was found to detect cardiac dysfunctions during weaning, and noninvasive cardiometry was considered a reliable tool that supports echocardiography for detecting changing trends in CI in PICUs. However, accurate values should be confirmed by echocardiography.
(© 2024. The Author(s).)
Databáze: MEDLINE
Externí odkaz: