Adaptations in hepatic glucose metabolism after chronic social defeat stress in mice.

Autor: Meijboom FS; Department for Developmental Origins of Disease (DDOD), Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Hasch A; Leibniz Institute for Resilience Research (LIR), Mainz, Germany., Ruiz de Azua I; Leibniz Institute for Resilience Research (LIR), Mainz, Germany.; Institute of Physiological Chemistry, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany., Cologna CT; Laboratory of Applied Mass Spectrometry, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium.; Center for Cancer Biology, Metabolomics Core Leuven, VIB, Leuven, Belgium., Loopmans S; Laboratory of Applied Mass Spectrometry, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium.; Center for Cancer Biology, Metabolomics Core Leuven, VIB, Leuven, Belgium., Lutz B; Leibniz Institute for Resilience Research (LIR), Mainz, Germany.; Institute of Physiological Chemistry, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany., Müller MB; Leibniz Institute for Resilience Research (LIR), Mainz, Germany.; Department of Psychiatry and Psychotherapy, Translational Psychiatry, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany., Ghesquière B; Laboratory of Applied Mass Spectrometry, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium.; Center for Cancer Biology, Metabolomics Core Leuven, VIB, Leuven, Belgium., van der Kooij MA; Department for Developmental Origins of Disease (DDOD), Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands. m.a.vanderkooij-9@umcutrecht.nl.; Leibniz Institute for Resilience Research (LIR), Mainz, Germany. m.a.vanderkooij-9@umcutrecht.nl.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2024 Oct 26; Vol. 14 (1), pp. 25511. Date of Electronic Publication: 2024 Oct 26.
DOI: 10.1038/s41598-024-76310-3
Abstrakt: Chronic stress has been shown to induce hyperglycemia in both peripheral blood and the brain, yet the detailed mechanisms of glucose metabolism under stress remain unclear. Utilizing 13 C 6 -labeled glucose to trace metabolic pathways, our study investigated the impact of stress by chronic social defeat (CSD) on glucose metabolites in the liver and brain one week post-stress. We observed a reduction in 13 C 6 -enrichment of glucose metabolites in the liver, contrasting with unchanged levels in the brain. Notably, hepatic glycogen levels were reduced while lactate concentrations were elevated, suggesting lactate as an alternative energy source during stress. Long-term effects were also examined, revealing normalized blood glucose levels and restored glycogen stores in the liver three weeks post-CSD, despite sustained increases in food intake. This normalization is hypothesized to result from diminished glucagon levels leading to reduced glycogen phosphorylase activity. Our findings highlight a temporal shift in glucose metabolism, with hyperglycemia and glycogen depletion in the liver early after CSD, followed by a later phase of metabolic stabilization. These results underscore the liver's critical role in adapting to CSD and provide insights into the metabolic adjustments that maintain glucose homeostasis under prolonged stress conditions.
(© 2024. The Author(s).)
Databáze: MEDLINE
Externí odkaz: