Organising pneumonia due to inadequately cleared COVID-19 infection while on rituximab.

Autor:	Olson CG; Division of Internal Medicine, Mayo Clinic in Florida, Jacksonvile, Florida, USA carolinegolson@gmail.com., Karime C; Division of Internal Medicine, Mayo Clinic in Florida, Jacksonvile, Florida, USA., Dawson N; Division of Internal Medicine, Mayo Clinic in Florida, Jacksonvile, Florida, USA.
Jazyk:	angličtina
Zdroj:	BMJ case reports [BMJ Case Rep] 2024 Oct 26; Vol. 17 (10). Date of Electronic Publication: 2024 Oct 26.
DOI:	10.1136/bcr-2023-259153
Abstrakt:	A male patient in his 70s with a history of tobacco use, organising pneumonia and rheumatoid arthritis that had been treated for several years with rituximab currently being treated with tocilizumab, presented with progressively worsening shortness of breath, increasing oxygen requirements and weakness. He had a history of COVID-19 infection 6 months prior to presentation. Initial COVID-19 PCR testing at presentation was negative. Bronchoalveolar lavage was positive for COVID-19 but negative for spike antibodies. It was thought that he did not clear his prior COVID-19 infection due to his immunocompromised state while taking rituximab. On recommendation of infectious disease, he was treated with a prolonged course of nirmatrelvir/ritonavir, remdesivir and corticosteroids with significant symptom improvement. Competing Interests: Competing interests: None declared. (© BMJ Publishing Group Limited 2024. No commercial re-use. See rights and permissions. Published by BMJ.)
Databáze:	MEDLINE
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