Evolution of the use, effectiveness and safety of bismuth-containing quadruple therapy for Helicobacter pylori infection between 2013 and 2021: results from the European registry on H. pylori management (Hp-EuReg).

Autor:	Olmedo L; Medicina, Programa de Doctorado en Ciencias de la Salud, Universitat Internacional de Catalunya, Sant Cugat del Valles, Barcelona, Spain.; ABS Manresa 3, Althaia Xarxa Assistencial Universitària de Manresa. Institut de Recerca i Innovació en Ciències de la Vida i de la Salut de la Catalunya Central (IRIS-CC), Manresa, Barcelona, Spain.; Gastrointestinal Oncology Endoscopy and Surgery (GOES) research group, Althaia Xarxa Assistencial Universitària de Manresa. Institut de Recerca i Innovació en Ciències de la Vida i de la Salut de la Catalunya Central (IRIS-CC), Manresa, Barcelona, Spain., Calvet X; Servei d'Aparell Digestiu, Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT-CERCA). Universitat Autònoma de Barcelona, Sabadell, Spain xcalvet@tauli.cat.; Centro de Investigación en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain., Gené E; Medicina, Programa de Doctorado en Ciencias de la Salud, Universitat Internacional de Catalunya, Sant Cugat del Valles, Barcelona, Spain.; Centro de Investigación en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain.; Servei d'Urgències, Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT-CERCA). Universitat Autònoma de Barcelona, Sabadell, Spain., Bordin DS; Department of Pancreatic, Biliary and Upper Digestive Tract Disorders, AS Loginov Moscow Clinical Scientific Center, Moscow, Russian Federation.; Department of Propaedeutic of Internal Diseases and Gastroenterology, Russian University of Medicine, Moscow, Russian Federation.; Department of Outpatient Therapy and Family Medicine, Tver State Medical University, Tver, Russian Federation., Voynovan I; Department of Gastroenterology, AS Loginov Moscow Clinical Scientific Center, Moscow, Russian Federation., Castro-Fernandez M; Centro de Investigación en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain.; Department of Gastroenterology, Hospital Universitario de Valme, Sevilla, Spain., Pabón-Carrasco M; Department of Gastroenterology, Hospital Universitario de Valme, Sevilla, Spain., Keco-Huerga A; Department of Gastroenterology, Hospital Universitario de Valme, Sevilla, Spain., Perez-Aisa Á; Department of Gastroenterology, Hospital Universitario Costa del Sol, Marbella, Spain.; Redes de Investigación Cooperativa Orientada a Resultados en Salud (RICORS), Marbella, Spain., Lucendo AJ; Centro de Investigación en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain.; Department of Gastroenterology, Hospital General de Tomelloso, Tomelloso, Spain.; Department of Gastroenterology, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IIS-Princesa), Madrid, Spain.; Department of Gastroenterology, Instituto de Investigación Sanitaria de Castilla-La Mancha (IDISCAM), Tomelloso, Spain., Rodrigo L; Department of Gastroenterology, University of Oviedo, Oviedo, Spain., Sarsenbaeva AS; Department of Gastroenterology, Chelyabinsk Regional Clinical Hospital, Chelyabinsk, Russian Federation., Khlinov IB; Department of faculty therapy and geriatrics, Ural State Medical University, Ekaterinburg, Russian Federation., Fadieienko G; Departments the Division for the Study of the Digestive diseases and its Comorbidity with Noncommunicable Diseases, Government Institution L.T. Malaya Therapy National Institute of NAMS, Kharkiv, Ukraine., Zaytsev O; First Clinical Medical Centre, Kovrov, Russian Federation., Lanas Á; Centro de Investigación en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain.; Department of Gastroenterology, Hospital Clínico Universitario Lozano Blesa, Zaragoza, Spain.; Instituto de Investigación Sanitaria de Aragón (IIS Aragón), Zaragoza, Spain., Martínez-Domínguez SJ; Centro de Investigación en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain.; Department of Gastroenterology, Hospital Clínico Universitario Lozano Blesa, Zaragoza, Spain.; Instituto de Investigación Sanitaria de Aragón (IIS Aragón), Zaragoza, Spain., Alfaro E; Department of Gastroenterology, Hospital Clínico Universitario Lozano Blesa, Zaragoza, Spain., Jonaitis L; Department of Gastroenterology, Lithuanian University of Health Sciences, Kaunas, Lithuania., Núñez Ó; Department of Gastroenterology, Hospital Universitario La Moraleja, Madrid, Spain.; Faculty of Medicine, Universidad Francisco de Vitoria, Madrid, Spain., Pellicano R; Department of Gastroenterology, Molinette-SGAS Hospital, Turin, Italy., Hernández L; Department of Gastroenterology, Hospital Santos Reyes, Aranda de Duero, Spain., Gridnyev O; Departments the Division for the Study of the Digestive diseases and its Comorbidity with Noncommunicable Diseases, Government Institution L.T. Malaya Therapy National Institute of NAMS, Kharkiv, Ukraine., Kupcinskas J; Institute for Digestive Research and Department of Gastroenterology, Lithuanian University of Health Sciences, Kaunas, Lithuania., Gasbarrini A; Department of Internal Medicine and Gastroenterology, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy., Boltin D; Department of Gastroenterology, Rabin Medical Center, Tel Aviv, Israel.; Tel Aviv University, Tel Aviv, Israel., Niv Y; Dr. Miriam and Sheldon G. Adelson School of Medicine, Ariel University, Ari'el, Israel., Babayeva G; Department of Therapy, Azerbaijan State Advanced Training Institute for Doctors named by A. Aliyev, Baku, Azerbaijan., Marcos-Pinto R; Department of Gastroenterology, Centro Hospitalar do Porto, Porto, Portugal.; Instituto De Ciências Biomédicas de Abel Salazar, Universidade do Porto, Porto, Portugal.; Center for Research in Health Technologies and Information Systems (CINTESIS), Porto, Portugal., Tepes B; Department of Gastroenterology, DC Rogaska, Rogaska Slatina, Slovenia., Venerito M; Department of Gastroenterology, Hepatology and Infectious Diseases, University Hospital of Magdeburg, Magdeburg, Germany., Papp V; Department of Surgery, Transplantation and Gastroenterology, Semmelweis University, Budapest, Hungary., Lerang F; Department of Gastroenterology, Østfold Hospital Trust, Grålum, Norway., Leja M; Department of Gastroenterology, Digestive Diseases Centre, Riga, Latvia.; Institute of Clinical and Preventive Medicine, University of Latvia, Riga, Latvia., Phull PS; Department of Digestive Disorders, Aberdeen Royal Infirmary, Aberdeen, UK., Marlicz W; Department of Gastroenterology, Pomeranian Medical University, Szczecin, Poland.; The Centre for Digestive Diseases, Endoklinika, Szczecin, Poland., Doulberis M; Department of Gastroenterology, Kantonsspital Aarau, Aarau, Switzerland., Smith SM; School of Medicine, Trinity College Dublin, Dublin, Ireland., Milivojevic V; Department of Gastroenterology and Hepatology, University Clinical Centre of Serbia, Belgrade University, Belgrade, Serbia., Kunovsky L; 2nd Department of Internal Medicine - Gastroenterology and Geriatrics, University Hospital Olomouc, Faculty of Medicine and Dentistry, Palacky University Olomouc, Olomouc, Czech Republic.; Department of Surgery, University Hospital Brno, Faculty of Medicine, Masaryk University, Brno, Czech Republic.; Department of Gastroenterology and Digestive Endoscopy, Masaryk Memorial Cancer Institute, Brno, Czech Republic., Mestrovic A; Department of Gastroenterology, University Hospital of Split, Split, Croatia., Matysiak-Budnik T; Department of Hepato-Gastroenterology & Digestive Oncology, University Hospital of Nantes, Nantes, France., Simsek H; Department of Gastroenterology, Hacettepe University, Ankara, Turkey.; Department of Gastroenterology, HC International Clinic, Ankara, Turkey., Cano-Català A; Gastrointestinal Oncology Endoscopy and Surgery (GOES) research group, Althaia Xarxa Assistencial Universitària de Manresa. Institut de Recerca i Innovació en Ciències de la Vida i de la Salut de la Catalunya Central (IRIS-CC), Manresa, Barcelona, Spain., Puig I; Gastrointestinal Oncology Endoscopy and Surgery (GOES) research group, Althaia Xarxa Assistencial Universitària de Manresa. Institut de Recerca i Innovació en Ciències de la Vida i de la Salut de la Catalunya Central (IRIS-CC), Manresa, Barcelona, Spain.; Department of Medicine, Facultat de Ciències de la Salut, Universitat de Vic-Universitat Central de Catalunya (UVic-UCC), Manresa, Spain., Moreira L; Centro de Investigación en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain.; Department of Gastroenterology, Hospital Clínic de Barcelona, Barcelona, Spain.; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.; University of Barcelona, Barcelona, Spain., Parra P; Centro de Investigación en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain.; Department of Gastroenterology, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IIS-Princesa), Madrid, Spain.; Universidad Autónoma de Madrid (UAM), Madrid, Spain., Nyssen OP; Centro de Investigación en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain.; Department of Gastroenterology, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IIS-Princesa), Madrid, Spain.; Universidad Autónoma de Madrid (UAM), Madrid, Spain., Megraud F; Université de Bordeaux, INSERM U1312 BRIC, Bordeaux, France., O'Morain C; Faculty of Health Sciences, Trinity College Dublin, Dublin, Ireland., Gisbert JP; Centro de Investigación en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain.; Department of Gastroenterology, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IIS-Princesa), Madrid, Spain.; Universidad Autónoma de Madrid (UAM), Madrid, Spain.
Jazyk:	angličtina
Zdroj:	Gut [Gut] 2024 Oct 26. Date of Electronic Publication: 2024 Oct 26.
DOI:	10.1136/gutjnl-2024-332804
Abstrakt:	Background: Bismuth quadruple therapies (BQTs) including bismuth, a proton pump inhibitor (PPI) and two antibiotics have been shown to be highly effective for treating Helicobacter pylori infection even in areas of high bacterial antibiotic resistance. Objective: To describe the time trends of use, effectiveness and safety of BQT in Europe using the European Registry on Helicobacter pylori Management (Hp-EuReg). Design: Patients registered in the Hp-EuReg from 2013 to 2021 who had received BQT were included. The regimens prescribed, the number of eradication attempts, effectiveness, adherence and safety were analysed. The effectiveness was assessed by modified intention to treat (mITT). Time-trend and multivariate analyses were performed to determine variables that predicted treatment success. Results: Of the 49 690 patients included in the Hp-EuReg, 15 582 (31%) had received BQT. BQT use increased from 8.6% of all treatments in 2013 to 39% in 2021. Single-capsule BQT-containing bismuth, metronidazole and tetracycline-plus a PPI (single-capsule BQT, ScBQT) was the most frequent treatment mode (43%). Schemes that obtained an effectiveness above 90% were the 10-day ScBQT and 14-day BQT using tetracycline plus metronidazole, or amoxicillin plus either clarithromycin or metronidazole. Only ScBQT achieved above 90% cure rates in all the geographical areas studied. Using the ScBQT scheme, adherence, the use of standard or high-dose PPIs, 14-day prescriptions and the use of BQT as first-line treatment were significantly associated with higher mITT effectiveness. Conclusion: The use of BQT increased notably in Europe over the study period. A 10-day ScBQT was the scheme that most consistently achieved optimal effectiveness. Trial Registration Number: NCT02328131. Competing Interests: Competing interests: XC has received research grants and fees for lectures from Allergan. JPG has served as speaker, consultant and advisory member for or has received research funding from Mayoly Spindler, Allergan, Diasorin, Richen, Biocodex and Juvisé. OPN received research funding from Allergan, Mayoly Spindler, Richen, Biocodex and Juvisé. DSB served as a lecturer for Astellas, AstraZeneca, KRKA and Abbott. FM is a consultant for PHATHOM, DaVoltera and has received grants from Allergan, bioMerieux and Mobidiag. The remaining authors declare no conflict of interest. (© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
Databáze:	MEDLINE
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