High dietary antioxidant index associated with reduced insulin resistance in female Mexican children and adolescents.

Autor: Jiménez-Ortega RF; Laboratorio de Genómica del Metabolismo Óseo, Instituto Nacional de Medicina Genómica (INMEGEN), Ciudad de México, México; Universidad Estatal del Valle de Ecatepec, Ecatepec de Morelos, Estado de México, México., Meneses-León J; Centro de Investigación en Políticas, Población y Salud de la Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad de México, México., Hernández S; Centro de Investigación en Políticas, Población y Salud de la Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad de México, México., Thebar-Moreno P; Centro de Investigación en Políticas, Población y Salud de la Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad de México, México., Aparicio-Bautista DI; Laboratorio de Genómica del Metabolismo Óseo, Instituto Nacional de Medicina Genómica (INMEGEN), Ciudad de México, México., Becerra-Cervera A; Laboratorio de Genómica del Metabolismo Óseo, Instituto Nacional de Medicina Genómica (INMEGEN), Ciudad de México, México; Consejo Nacional de Humanidades, Ciencias y Tecnologías (CONAHCYT), Mexico City, Mexico., Aguilar-Salinas C; Escuela de Medicina y Ciencias de la Salud, Tecnologico de Monterrey, Mexico City, Mexico; Unidad de Investigación de Enfermedades Metabólicas, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico., Salmerón J; Centro de Investigación en Políticas, Población y Salud de la Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad de México, México., Rivera-Paredez B; Centro de Investigación en Políticas, Población y Salud de la Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad de México, México., Velázquez-Cruz R; Laboratorio de Genómica del Metabolismo Óseo, Instituto Nacional de Medicina Genómica (INMEGEN), Ciudad de México, México. Electronic address: rvelazquez@inmegen.gob.mx.
Jazyk: angličtina
Zdroj: Nutrition research (New York, N.Y.) [Nutr Res] 2024 Sep 28; Vol. 132, pp. 53-66. Date of Electronic Publication: 2024 Sep 28.
DOI: 10.1016/j.nutres.2024.09.016
Abstrakt: Antioxidant intake is inversely associated with different health outcomes; however, its association with insulin resistance (IR) has not been well documented. We hypothesized that the Dietary Antioxidant Index (DAI) is inversely associated with IR in Mexican children and adolescents. A cross-sectional analysis was performed using data from the Health Workers Cohort Study. A total of 830 children and adolescents aged 7 to 18 years were enrolled. The DAI was evaluated in three categories defined by tertiles using a semiquantitative food frequency questionnaire. IR was defined using previously reported cutoff points in the homeostasis model assessment. This association was evaluated using a multiple logistic regression model. Stratified analysis was performed using body mass index and sex. The prevalence of IR based on the DAI categories (low, medium, high) was 23.8%, 24.2%, and 15.3%, respectively. The IR odds ratio (OR) for participants in the highest DAI category was 0.49 (95% confidence interval [CI]: 0.30-0.80). Notably, female Children and Adolescents in the highest DAI category had significantly lower odds of developing IR than those in the lowest DAI category (OR 0.54, 95% CI 0.29-0.98). Participants with overweight/obesity showed a similar association (OR 0.37, 95% CI 0.18-0.76). These results suggest that the DAI is inversely associated with IR, particularly in females, highlighting the potential role of antioxidants in preventing IR. This underscores the need to establish recommendations for antioxidant consumption in female children and adolescents.
Competing Interests: Author declarations None.
(Copyright © 2024 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: