Confronting synchronous multiple primary lung cancers: Navigating the intersection of challenges and opportunities.

Autor: He X; Department of Thoracic Surgery, The Second Xiangya Hospital of Central South University, Changsha, Hunan, PR China., Yang Z; Department of Thoracic Surgery, The Second Xiangya Hospital of Central South University, Changsha, Hunan, PR China., Wu F; Department of Oncology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, PR China., Liang Q; Department of Pathology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, PR China., Liu W; Department of Thoracic Surgery, The Second Xiangya Hospital of Central South University, Changsha, Hunan, PR China; Hunan Key Laboratory of Early Diagnosis and Precise Treatment of Lung Cancer, The Second Xiangya Hospital of Central South University, Changsha, Hunan, PR China., Yu F; Department of Thoracic Surgery, The Second Xiangya Hospital of Central South University, Changsha, Hunan, PR China; Hunan Key Laboratory of Early Diagnosis and Precise Treatment of Lung Cancer, The Second Xiangya Hospital of Central South University, Changsha, Hunan, PR China., Chen C; Department of Thoracic Surgery, The Second Xiangya Hospital of Central South University, Changsha, Hunan, PR China; Hunan Key Laboratory of Early Diagnosis and Precise Treatment of Lung Cancer, The Second Xiangya Hospital of Central South University, Changsha, Hunan, PR China. Electronic address: chenchen1981412@csu.edu.cn.
Jazyk: angličtina
Zdroj: Lung cancer (Amsterdam, Netherlands) [Lung Cancer] 2024 Nov; Vol. 197, pp. 107994. Date of Electronic Publication: 2024 Oct 22.
DOI: 10.1016/j.lungcan.2024.107994
Abstrakt: The increased detection of synchronous multiple primary lung cancers (sMPLC) through advanced computed tomography underscores the necessity for innovative therapeutic approaches. sMPLC typically manifests as ground-glass opacities, mixed ground-glass opacities, and/or solid nodules, predominantly in early-stage, non-smoking female patients, with a majority being adenocarcinomas. The high prevalence of EGFR mutations and considerable heterogeneity among lesions pose distinct diagnostic and therapeutic challenges for sMPLC. This study provides a comprehensive review and analysis of recent clinical and radiological studies, genomic profiling, and the efficacy of the "Surgery + X" treatment model for sMPLC. Additionally, the article discusses several intricate and complex sMPLC cases, shedding light on the disease's complexities and identifying existing gaps and potential breakthroughs in clinical diagnosis, treatment, and research. It underscores the critical role of a multidisciplinary approach and advocates for targeted research on sMPLC, highlighting its potential to impact lung cancer research significantly.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 The Author(s). Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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