Immune Checkpoint Blockade Therapies Efficacy and Toxicity in Patients With Impaired Renal Function in Metastatic Bladder Cancer.

Autor: Tural D; Medical Oncology, Koc University Medical Faculty, Istanbul, Turkey. Electronic address: deniztural@gmail.com., Arslan C; Faculty of Medicine, Department of Medical Oncology, İzmir University of Economics, İzmir, Turkey., Selcukbiricik F; Medical Oncology, Koc University Medical Faculty, Istanbul, Turkey., Olmez OF; Medical Oncology, Medipol University Hospital, Istanbul, Turkey., Akar E; Medical Oncology, Koc University Medical Faculty, Istanbul, Turkey., Erman M; Medical Oncology, Hacettepe University Medical Faculty, Ankara, Turkey., Ürün Y; Medical Oncology, Ankara University Medical Faculty, Ankara, Turkey., Erdem D; Medical Oncology, Medical Park Samsun Hospital, Samsun, Turkey., Kilickap S; Medical Oncology, Liv Hospital, Istinye University, Ankara, Turkey.
Jazyk: angličtina
Zdroj: Clinical genitourinary cancer [Clin Genitourin Cancer] 2024 Dec; Vol. 22 (6), pp. 102228. Date of Electronic Publication: 2024 Oct 04.
DOI: 10.1016/j.clgc.2024.102228
Abstrakt: Background: In this study, we reported the real-life results of data from impaired renal patients with urothelial carcinoma who were treated with ICTs.
Methods: The patients were categorized into 3 different groups GFR ≥60mL/min (normal), 60mL/min-30mL/min (low), and less than 30 mL/min (very low) based on GFR. The primary endpoints were the overall response rate (ORR), overall survival (OS), duration of response with ICT, and safety. Median follow-up and OS were estimated by using the Kaplan-Meier method.
Results: One hundred-five (60.3%) of patients were GFR normal, 26.4% were GFR low with 30mL/min-60mL/min, and 13.2% were very low group. ORR for GFR normal, low and very low groups were 36% (n = 38), 26% (n = 12) and %31 (7); P = .2, respectively. The median duration of response for GFR normal, low and very low groups were 47.2 months (95% CI, 24.5-51.4), 33.1 months (95% CI, 26.9-47), and 23.5 months (95% CI, 12.2-43.7); P = .01, respectively. The Median OS rate for GFR normal, low and very low groups were 11.9 (7.2-16.5) months, 4.7 (1.8-7.7) and 6.8 (1.1-13.6) months, P = .015, respectively. In addition, GFR <60 ml/min HR = 1.6; 95% CI 1.12-1.80; P = .02, maintained a significant association with OS in multivariate analysis.
Conclusions: Long-term follow-up of real-world data confirms that the overall survival rate and durable response rate with ICT were higher in patients with GFR >60mL/min. On the other hand, we demonstrated that ICT was effective and a durable response seen in a group of patients with renal inpairement who did not have an effective systemic treatment option.
Competing Interests: Disclosure The authors have stated that they have no conflicts of interest.
(Copyright © 2024 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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