| Autor: |
Xu J; College of Plant Protection, Northwest A&F University, Yangling 712100, Shaanxi, China., Dou Z; College of Plant Protection, Northwest A&F University, Yangling 712100, Shaanxi, China., Zuo S; College of Plant Protection, Northwest A&F University, Yangling 712100, Shaanxi, China., Lv M; College of Plant Protection, Northwest A&F University, Yangling 712100, Shaanxi, China.; School of Marine Sciences, Ningbo University, Ningbo 315211, Zhejiang, China., Wang Y; College of Plant Protection, Northwest A&F University, Yangling 712100, Shaanxi, China., Hao M; College of Plant Protection, Northwest A&F University, Yangling 712100, Shaanxi, China., Chen L; College of Plant Protection, Yangzhou University, Yangzhou 225009, Jiangsu, China., Xu H; College of Plant Protection, Northwest A&F University, Yangling 712100, Shaanxi, China.; School of Marine Sciences, Ningbo University, Ningbo 315211, Zhejiang, China. |
| Abstrakt: |
Recently, research and development of novel pesticides from natural plant products have received much attention. To accelerate the application of sophocarpine as the agrochemical candidate, a series of novel sophocarpine-based isoxazoline derivatives were prepared by the 1,3-dipolar [2 + 3] cycloaddition reaction of sophocarpine with different chloroximes. Their structures were well characterized by high-resolution mass spectra, infrared spectra, and proton/carbon-13 nuclear magnetic resonance spectra. Eight steric configurations of compounds 5a , 5e' , 5f , 5g , 5h , 5i , 5r , and 5u' were further determined by X-ray single-crystallography. Against Aphis citricola Van der Goot, compounds 5n (LD 50 : 0.032 μg/nymph) and 5o (LD 50 : 0.024 μg/nymph) exhibited greater than 3.7- and 4.9-fold potent aphicidal activity compared to sophocarpine (LD 50 : 0.118 μg/nymph). Against Tetranychus cinnabarinus Boisduval, derivative 5g displayed the most promising acaricidal activity with the LC 50 value of 0.247 mg/mL, which was 14.2-fold that of sophocarpine. Compounds 5d and 5g also exhibited good control efficacy against T. cinnabarinus . Scanning electron microscopy images indicated that compound 5g can destroy the mite cuticle layer. These results will provide the foundation for the structural modification and use of sophocarpine derivatives as agrochemicals in the future. |
