Monocyte and Macrophage Functions in Oncogenic Viral Infections.

Autor: Echevarria-Lima J; Laboratório de Imunologia Básica e Aplicada, Department of Immunology, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro 21941-902, Brazil., Moles R; Department of Cell and Molecular Biology, University of Mississippi Medical Center, Jackson, MS 39216, USA.; Cancer Center and Research Institute, University of Mississippi Medical Center, Jackson, MS 39216, USA.; Center for Immunology and Microbial Research, University of Mississippi Medical Center, Jackson, MS 39216, USA.
Jazyk: angličtina
Zdroj: Viruses [Viruses] 2024 Oct 15; Vol. 16 (10). Date of Electronic Publication: 2024 Oct 15.
DOI: 10.3390/v16101612
Abstrakt: Monocytes and macrophages are part of innate immunity and constitute the first line of defense against pathogens. Bone marrow-derived monocytes circulate in the bloodstream for one to three days and then typically migrate into tissues, where they differentiate into macrophages. Circulatory monocytes represent 5% of the nucleated cells in normal adult blood. Following differentiation, macrophages are distributed into various tissues and organs to take residence and maintain body homeostasis. Emerging evidence has highlighted the critical role of monocytes/macrophages in oncogenic viral infections, mainly their crucial functions in viral persistence and disease progression. These findings open opportunities to target innate immunity in the context of oncogenic viruses and to explore their potential as immunotherapies.
Databáze: MEDLINE
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