Silk Fibroin Nanofibers: Advancements in Bioactive Dressings through Electrospinning Technology for Diabetic Wound Healing.

Autor: Aldahish A; Department of Pharmacology, College of Pharmacy, King Khalid University, Abha, Saudi Arabia., Shanmugasundaram N; Department of Pharmacology, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur, Chengalpattu 603203, India., Vasudevan R; Department of Pharmacology, College of Pharmacy, King Khalid University, Abha, Saudi Arabia., Alqahtani T; Department of Pharmacology, College of Pharmacy, King Khalid University, Abha, Saudi Arabia., Alqahtani S; Department of Pharmacology, College of Pharmacy, King Khalid University, Abha, Saudi Arabia., Mohammad Asiri A; Khamis Mushayt General Hospital, Aseer Health Cluster, Ministry of Health, Khamis Mushait 62433, Saudi Arabia., Devanandan P; Department of Pharmacy Practice, St. Peter's Institute of Pharmaceutical Sciences, Vidya Nagar, Hanamkonda 506001, India., Thamaraikani T; Department of Pharmacology, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur, Chengalpattu 603203, India., Vellapandian C; Department of Pharmacology, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur, Chengalpattu 603203, India., Jayasankar N; Department of Pharmacology, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur, Chengalpattu 603203, India.
Jazyk: angličtina
Zdroj: Pharmaceuticals (Basel, Switzerland) [Pharmaceuticals (Basel)] 2024 Sep 30; Vol. 17 (10). Date of Electronic Publication: 2024 Sep 30.
DOI: 10.3390/ph17101305
Abstrakt: Background: Non-healing diabetic wounds represent a significant clinical challenge globally, necessitating innovative approaches in drug delivery to enhance wound healing. Understanding the pathogenesis of these wounds is crucial for developing effective treatments. Bioactive dressings and polymeric nanofibers have emerged as promising modalities, with silk biomaterials gaining attention for their unique properties in diabetic wound healing.
Purpose of Review: The purpose of this review is to examine the challenges and innovations in treating non-healing diabetic wounds, emphasizing the global burden and the need for effective solutions. This review explores the complex mechanisms of wound healing in diabetes and evaluates the therapeutic potential of bioactive dressings and polymeric nanofibers. Special focus is given to the application of silk biomaterials, particularly silk fibroin, for wound healing, detailing their properties, mechanisms, and clinical translation. This review also describes various nanofiber fabrication methods, especially electrospinning technology, and presents existing evidence on the effectiveness of electrospun silk fibroin formulations.
Recent Findings: Recent advancements highlight the potential of silk biomaterials in diabetic wound healing, owing to their biocompatibility, mechanical strength, and controlled drug release properties. Electrospun silk fibroin-based formulations have shown promising results in preclinical and clinical studies, demonstrating accelerated wound closure and tissue regeneration.
Summary: Non-healing diabetic wounds present a significant healthcare burden globally, necessitating innovative therapeutic strategies. Bioactive dressings and polymeric nanofibers, particularly silk-based formulations fabricated through electrospinning, offer promising avenues for enhancing diabetic wound healing. Further research is warranted to optimize formulation parameters and validate efficacy in larger clinical trials.
Databáze: MEDLINE
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