| Autor: |
Dobrea CM; Preclinical Department, Faculty of Medicine, 'Lucian Blaga' University of Sibiu, 550169 Sibiu, Romania., Frum A; Preclinical Department, Faculty of Medicine, 'Lucian Blaga' University of Sibiu, 550169 Sibiu, Romania., Butuca A; Preclinical Department, Faculty of Medicine, 'Lucian Blaga' University of Sibiu, 550169 Sibiu, Romania., Morgovan C; Preclinical Department, Faculty of Medicine, 'Lucian Blaga' University of Sibiu, 550169 Sibiu, Romania., Stoicescu L; Internal Medicine Department, Faculty of Medicine, 'Iuliu Haţieganu' University of Medicine and Pharmacy, 400000 Cluj-Napoca, Romania.; Cardiology Department, Clinical Municipal Hospital, 400139 Cluj-Napoca, Romania., Chis AA; Preclinical Department, Faculty of Medicine, 'Lucian Blaga' University of Sibiu, 550169 Sibiu, Romania., Arseniu AM; Preclinical Department, Faculty of Medicine, 'Lucian Blaga' University of Sibiu, 550169 Sibiu, Romania., Rus LL; Preclinical Department, Faculty of Medicine, 'Lucian Blaga' University of Sibiu, 550169 Sibiu, Romania., Gligor FG; Preclinical Department, Faculty of Medicine, 'Lucian Blaga' University of Sibiu, 550169 Sibiu, Romania., Vonica-Tincu AL; Preclinical Department, Faculty of Medicine, 'Lucian Blaga' University of Sibiu, 550169 Sibiu, Romania. |
| Abstrakt: |
As the most common psychiatric symptom, depression represents a subject of high interest for the medical community. Background/Objectives : International guidelines consider selective serotonin reuptake inhibitors (SSRIs) the first-line treatment of depression. Although having better efficacy and tolerability in comparison to tricyclic antidepressants or monoamine oxidase inhibitors, the diversity and potential severity of adverse effects and interactions manifested by SSRIs, combined with the frequency of prescriptions, lead to the necessity of evaluating real-world data. The aim of this study was to identify and evaluate the drug interactions reported in EudraVigilance (EV) for the six SSRIs representatives that are authorized in Europe: fluoxetine (FXT), fluvoxamine (FVM), citalopram (CIT), escitalopram (ESC), paroxetine (PAR) and sertraline (SER). The entire class of SSRIs was examined as a comparator to identify whether one of the representatives was more prone to reporting. Methods : Descriptive analysis and disproportionality analysis were conducted on data extracted from the EV database. Results : A total of 326,450 adverse reactions (ADRs) were reported for the SSRIs group. Approximately a quarter of these (n = 83,201; 25.46%) were reported for SER and 22.37% (n = 73,131) for PAR. Of the total ADRs reported, 2.12% (n = 6925) represent preferred terms related to drug-drug interactions (DDIs): SER (n = 1474; 22.37%), CIT (n = 1272, 19.86), and FXT (n = 1309, 19.83%). Specific ADRs related to inhibitory activity represent 0.98%, and for potentiating activity, 1.89%. Conclusions : Although representing a small value of the total ADRs, DDIs may be related to severe outcomes. Awareness should be raised for this category of ADRs that can be reduced by the joined efforts of physicians and pharmacists. |
