| Autor: |
Lima GB; Postgraduate Program in Nutrition and Health, Faculty of Nutrition, Federal University of Goiás (UFG), Goiânia 74690-900, Brazil., Figueiredo N; Postgraduate Program in Health Sciences, Faculty of Medicine, Federal University of Goiás (UFG), Goiânia 74690-900, Brazil., Kattah FM; Postgraduate Program in Nutrition and Health, Faculty of Nutrition, Federal University of Goiás (UFG), Goiânia 74690-900, Brazil., Oliveira ES; Postgraduate Program in Nutrition and Health, Faculty of Nutrition, Federal University of Goiás (UFG), Goiânia 74690-900, Brazil., Horst MA; Postgraduate Program in Nutrition and Health, Faculty of Nutrition, Federal University of Goiás (UFG), Goiânia 74690-900, Brazil., Dâmaso AR; Interdisciplinary Postgraduate Program in Health Sciences, Federal University of São Paulo (UNIFESP), São Paulo 04039-032, Brazil., Oyama LM; Interdisciplinary Postgraduate Program in Health Sciences, Federal University of São Paulo (UNIFESP), São Paulo 04039-032, Brazil., Whitton RGM; Institute of Biosciences, Federal University of São Paulo (USP), São Paulo 05508-900, Brazil., de Souza GIMH; Interdisciplinary Postgraduate Program in Health Sciences, Federal University of São Paulo (UNIFESP), São Paulo 04039-032, Brazil., Lima GC; Postgraduate Program in Nutrition and Health, Faculty of Nutrition, Federal University of Goiás (UFG), Goiânia 74690-900, Brazil., Mota JF; Postgraduate Program in Nutrition and Health, Faculty of Nutrition, Federal University of Goiás (UFG), Goiânia 74690-900, Brazil.; Postgraduate Program in Health Sciences, Faculty of Medicine, Federal University of Goiás (UFG), Goiânia 74690-900, Brazil., Campos RMS; Interdisciplinary Postgraduate Program in Health Sciences, Federal University of São Paulo (UNIFESP), São Paulo 04039-032, Brazil., Corgosinho FC; Postgraduate Program in Nutrition and Health, Faculty of Nutrition, Federal University of Goiás (UFG), Goiânia 74690-900, Brazil.; Postgraduate Program in Health Sciences, Faculty of Medicine, Federal University of Goiás (UFG), Goiânia 74690-900, Brazil. |
| Abstrakt: |
Background: Inflammation plays a central role in many chronic diseases that characterize modern society. Leptin/adiponectin and adiponectin/leptin ratios have been recognized as notable markers of dysfunctional adipose tissue and, consequently, an inflammatory state. Methods: Blood samples were collected from 41 adult volunteers (40.2 ± 8.3 years) diagnosed with severe obesity (BMI 46.99; 42.98-51.91 kg/m 2 ). The adipokines were quantified using an enzyme-linked immunosorbent assay, while the serum fatty acid analysis was conducted using chromatography. Results: The results unveiled a positive correlation between the leptin/adiponectin ratio and the 20:3n6 fatty acid (r = 0.52, p = 0.001), as well as a similar positive correlation between the adiponectin/leptin ratio and the 22:6n3 fatty acid (r = 0.74, p = 0.001). In the regression analysis, the 22:6n3 fatty acid predicted the adiponectin/leptin ratio (β = 0.76, p < 0.001), whereas C20:3 n-6 was a predictor for inflammatory markers (β = 4.84, p < 0.001). Conclusions: In conclusion, the 22:6n3 fatty acid was demonstrated to be a predictive factor for the adiponectin/leptin ratio and C20:3 n-6 was a predictor for inflammatory markers. This discovery, novel within this population, can help develop new intervention strategies aimed at controlling the inflammatory status in individuals classified as having severe obesity. |
