| Autor: |
Rodrigues Barreto I; CICS-UBI-Health Sciences Research Centre, University of Beira Interior, Av. Infante D. Henrique, 6200-506 Covilhã, Portugal., Monteiro A; Faculty of Health Sciences, University of Beira Interior, 6200-506 Covilhã, Portugal.; Clinical Pathology Service, Centro Hospitalar Universitário da Cova da Beira (CHUCB), Alameda Pêro da Covilhã, 6200-251 Covilhã, Portugal., Rocha EF; ULS Castelo Branco, Avenida Pedro Alvares Cabral, 6000-085 Castelo Branco, Portugal., Santos CR; Faculty of Health Sciences, University of Beira Interior, 6200-506 Covilhã, Portugal.; ULS Castelo Branco, Avenida Pedro Alvares Cabral, 6000-085 Castelo Branco, Portugal., Fonseca AM; CICS-UBI-Health Sciences Research Centre, University of Beira Interior, Av. Infante D. Henrique, 6200-506 Covilhã, Portugal.; Faculty of Health Sciences, University of Beira Interior, 6200-506 Covilhã, Portugal. |
| Abstrakt: |
Introduction: Patients undergoing hemodialysis (HD) often exhibit an impaired cellular immune response, which may contribute to an increased susceptibility to infections and other complications. Th1 cells, a subset of T-helper cells, play a crucial role in cellular immunity. However, the modulation of Th1 cells by HD treatment remains unclear. Objective: This study aims to investigate the levels of circulating T cells, especially Th1 cells, and the neutrophil-to-lymphocyte ratio (NLR) in HD patients. Methods : We recruited 26 HD patients and 10 healthy volunteers. Demographical data were collected, and peripheral blood samples were analyzed. Absolute blood cell counts were determined, and T-cell populations were identified using flow cytometry. Th1 cells were defined as IFN-γ-producing CD4 + T cells after in vitro activation, and NLR was calculated through the ratio between the neutrophil and lymphocyte counts measured in peripheral blood. Results: We have observed a significant decrease in Th1 subpopulation frequency in HD patients, as well as significant correlations between immunological and demographic parameters, among which are the NLR values and the absolute values of T-cell subsets. Conclusions: These results seem to clarify the role of Th1 cells in modulating the immune responses of hemodialysis-treated patients, potentially considering its frequency as an indicator for CKD development. |
