| Autor: |
Martins RA; Medical School, Tiradentes University Center, Maceió 57038-000, Brazil., Costa FR; Department of Orthopedics, FC Sports Traumatology, Salvador 40296-210, Brazil., Pires L; Department of Orthopedics, Brazilian Institute of Regenerative Medicine (BIRM), Indaiatuba 13334-170, Brazil.; Regenerative Medicine, Orthoregen International Course, Indaiatuba 13334-170, Brazil., Santos M; Nutritional Sciences, Metropolitan Union of Education and Culture, Salvador 42700-000, Brazil., Santos GS; Department of Orthopedics, Brazilian Institute of Regenerative Medicine (BIRM), Indaiatuba 13334-170, Brazil.; Regenerative Medicine, Orthoregen International Course, Indaiatuba 13334-170, Brazil., Lana JV; Medical School, Max Planck University Center (UniMAX), Indaiatuba 13343-060, Brazil., Costa BR; Medical School, Zarns College, Salvador 41720-200, Brazil., Santos N; Department of Orthopedics, Brazilian Institute of Regenerative Medicine (BIRM), Indaiatuba 13334-170, Brazil.; Regenerative Medicine, Orthoregen International Course, Indaiatuba 13334-170, Brazil., de Macedo AP; Department of Orthopedics, Brazilian Institute of Regenerative Medicine (BIRM), Indaiatuba 13334-170, Brazil.; Regenerative Medicine, Orthoregen International Course, Indaiatuba 13334-170, Brazil., Kruel A; Regenerative Medicine, Orthoregen International Course, Indaiatuba 13334-170, Brazil., Lana JF; Department of Orthopedics, Brazilian Institute of Regenerative Medicine (BIRM), Indaiatuba 13334-170, Brazil.; Regenerative Medicine, Orthoregen International Course, Indaiatuba 13334-170, Brazil.; Medical School, Max Planck University Center (UniMAX), Indaiatuba 13343-060, Brazil.; Clinical Research, Anna Vitória Lana Institute (IAVL), Indaiatuba 13334-170, Brazil.; Medical School, Jaguariúna University Center (UniFAJ), Jaguariúna 13911-094, Brazil. |
| Abstrakt: |
The buffy-coat, a layer of leukocytes and platelets obtained from peripheral blood centrifugation, plays a crucial role in tissue regeneration and the modulation of inflammatory responses. This article explores the mechanisms of regenerative inflammation, highlighting the critical role of the buffy-coat in influencing macrophage polarization and its therapeutic potential. Macrophage polarization into M1 and M2 subtypes is pivotal in balancing inflammation and tissue repair, with M1 macrophages driving pro-inflammatory responses and M2 macrophages promoting tissue healing and regeneration. The buffy-coat's rich composition of progenitor cells, cytokines, and growth factors-such as interleukin-10, transforming growth factor-β, and monocyte colony-stimulating factor-supports the transition from M1 to M2 macrophages, enhancing tissue repair and the resolution of inflammation. This dynamic interaction between buffy-coat components and macrophages opens new avenues for therapeutic strategies aimed at improving tissue regeneration and managing inflammatory conditions, particularly in musculoskeletal diseases such as osteoarthritis. Furthermore, the use of buffy-coat-derived therapies in conjunction with other regenerative modalities, such as platelet-rich plasma, holds promise for more effective clinical outcomes. |
