Radiotherapy with 15 × 2.633 Gy vs. 20 × 2.0 Gy in Patients with Malignant Spinal Cord Compression and Favorable Survival Prognoses: A Secondary Analysis of the RAMSES-01 Trial.

Autor: Rades D; Department of Radiation Oncology, University of Lubeck, 23562 Lubeck, Germany., Lomidze D; Radiation Oncology Department, Tbilisi State Medical University, Tbilisi 0177, Georgia.; Radiation Oncology Department, Ingorokva High Medical Technology University Clinic, Tbilisi 0177, Georgia., Jankarashvili N; Department of Radiation Oncology, Acad. F. Todua Medical Center-Research Institute of Clinical Medicine, Tbilisi 0112, Georgia., Lopez Campos F; Department of Radiation Oncology, University Hospital Ramón y Cajal, 28034 Madrid, Spain., Navarro-Martin A; Department of Radiation Oncology, Instituto Catalán de Oncología, 08908 l'Hospitalet de Llobregat, Barcelona, Spain., Segedin B; Department of Radiotherapy, Institute of Oncology Ljubljana, 1000 Ljubljana, Slovenia.; Department of Radiotherapy, Faculty of Medicine, University of Ljubljana, 1000 Ljubljana, Slovenia., Groselj B; Department of Radiotherapy, Institute of Oncology Ljubljana, 1000 Ljubljana, Slovenia.; Department of Radiotherapy, Faculty of Medicine, University of Ljubljana, 1000 Ljubljana, Slovenia., Staackmann C; Department of Radiation Oncology, University of Lubeck, 23562 Lubeck, Germany., Yu NY; Department of Radiation Oncology, Mayo Clinic, Phoenix, AZ 85054, USA., Cacicedo J; Department of Radiation Oncology, Cruces University Hospital, 48903 Barakaldo, Bizkaia, Spain.; Department of Radiation Oncology, Biobizkaia Health Research Institute, 48903 Barakaldo, Bizkaia, Spain.
Jazyk: angličtina
Zdroj: Cancers [Cancers (Basel)] 2024 Oct 10; Vol. 16 (20). Date of Electronic Publication: 2024 Oct 10.
DOI: 10.3390/cancers16203436
Abstrakt: Many patients with malignant spinal cord compression (MSCC) who are not candidates for neurosurgery receive radiotherapy alone. This study compared 15 × 2.633 Gy over three weeks to 20 × 2.0 Gy over four weeks in patients with favorable survival prognoses. The outcomes of 34 patients treated with 15 × 2.633 Gy (equivalent dose 41.6 Gy 10 ) in the RAMSES-01 trial were compared to 239 patients from an existing database receiving 20 × 2.0 Gy using propensity-score-adjusted Cox and logistic regression models. All patients had favorable survival prognoses. Endpoints included local progression-free survival (LPFS), improvement of motor function, post-treatment ambulatory status, and overall survival (OS). After propensity score adjustment, the 12-month rates of LPFS and OS were 98.1% (RAMSES-01 cohort) vs. 91.6% ( p = 0.265) and 79.1% vs. 82.2% ( p = 0.704), respectively. Regarding improvement of motor function, 15 × 2.633 Gy appeared superior ( p = 0.073). No significant difference was observed regarding ambulatory status ( p = 0.822). The three-week regimen for MSCC has similar outcomes and reduces treatment time when compared to a four-week regimen.
Databáze: MEDLINE
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