Oxytocin in neurodevelopmental disorders: Autism spectrum disorder and Prader-Willi syndrome.

Autor: Josselsohn A; Albert Einstein College of Medicine, Montefiore Medical Center, 1225 Morris Park Avenue Bronx, NY 10461, USA; Temple University, College of Education and Human Development, 1301 Cecil B. Moore Ave, Philadelphia, PA 19122, USA., Zhao Y; Albert Einstein College of Medicine, Montefiore Medical Center, 1225 Morris Park Avenue Bronx, NY 10461, USA., Espinoza D; Albert Einstein College of Medicine, Montefiore Medical Center, 1225 Morris Park Avenue Bronx, NY 10461, USA; SUNY Upstate Medical University, 750 E Adams St, Syracuse, NY 13210, USA., Hollander E; Albert Einstein College of Medicine, Montefiore Medical Center, 1225 Morris Park Avenue Bronx, NY 10461, USA. Electronic address: eholland@montefiore.org.
Jazyk: angličtina
Zdroj: Pharmacology & therapeutics [Pharmacol Ther] 2024 Dec; Vol. 264, pp. 108734. Date of Electronic Publication: 2024 Oct 23.
DOI: 10.1016/j.pharmthera.2024.108734
Abstrakt: This manuscript reviews recent work on oxytocin and its use in neurodevelopmental disorders including spectrum disorder (ASD) and Prader-Willi syndrome (PWS). Oxytocin is involved in social recognition, bonding, maternal behaviors, anxiety, food motivation, and hyperphagia. While the pathophysiology of ASD and PWS involve abnormalities in the oxytocin system, clinical trials have shown discrepant results in the effectiveness of oxytocin as a treatment for core symptoms associated with these disorders. In this review, we outline oxytocin's clinical pharmacology, safety considerations, and results in recent clinical trials. We propose that oxytocin may be most beneficial in these populations if dosed in a dynamic regimen (PRN) and paired with social interventions.
Competing Interests: Declaration of competing interest Dr. Hollander reported being the recipient of research grants from the U.S. Department of Defense, the U.S. Food and Drug Administration, GW Pharma, F. Hoffmann-La Roche Ltd.; editorial stipends from Elsevier; and serving on scientific advisory boards for GW Pharma and F. Hoffmann-La Roche Ltd.
(Copyright © 2024. Published by Elsevier Inc.)
Databáze: MEDLINE
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