Tea polyphenol nano-crosslinked dynamical hyaluronic acid-based hydrogel for diabetic wound healing.

Autor: Liu H; School of Chemistry and Chemical Engineering, Beijing Institute of Technology, 100081 Beijing, China., Ai R; School of Chemistry and Chemical Engineering, Beijing Institute of Technology, 100081 Beijing, China., Liu BZ; School of Chemistry and Chemical Engineering, Beijing Institute of Technology, 100081 Beijing, China., He L; School of Chemistry and Chemical Engineering, Beijing Institute of Technology, 100081 Beijing, China. Electronic address: bit_lh@bit.edu.cn.
Jazyk: angličtina
Zdroj: International journal of biological macromolecules [Int J Biol Macromol] 2024 Dec; Vol. 282 (Pt 1), pp. 136856. Date of Electronic Publication: 2024 Oct 23.
DOI: 10.1016/j.ijbiomac.2024.136856
Abstrakt: Diabetic wound healing remains a significant clinical challenge for the complex wound microenvironment characterized by oxidative stress, inflammation, and bacterial infection. To address these challenges, we present a novel hydrogel incorporates tea polyphenol-stabilized silver nanoparticles (TP@Ag NPs) into a dynamic hyaluronic acid-phenylboronic acid network crosslinked via borate ester bonds. This design leverages the inherent biocompatibility and biodegradability of hyaluronic acid alongside the antioxidant, anti-inflammatory, and antibacterial properties of tea polyphenols and silver nanoparticles. The HP-TP@Ag hydrogel exhibited glucose-responsive degradation and TP@Ag NPs release, enabling targeted delivery within the diabetic wound microenvironment. In vitro assays demonstrated the hydrogel's potent antioxidant activity, effectively scavenging ROS and protecting both HaCaT and RAW264.7 cells from oxidative stress. Furthermore, the HP-TP@Ag hydrogel significantly suppressed the production of pro-inflammatory cytokines and exhibited robust antibacterial activity against both E. coli and S. aureus. In vivo studies using a diabetic mouse model revealed accelerated wound closure, reduced inflammation, enhanced collagen deposition, and promoted angiogenesis and tissue remodeling in HP-TP@Ag hydrogel-treated wounds. These findings highlight the promise of HP-TP@Ag hydrogel as an advanced wound dressing for effective diabetic wound management, offering a synergistic approach to overcome the multifaceted challenges associated with this complex condition.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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