Postanesthetic rhabdomyolysis in 7 warmblood horses.

Autor:	Hepworth-Warren KL; 1College of Veterinary Medicine, North Carolina State University, Raleigh, NC., Goldsmith D; 2University of Calgary, Calgary, AB, Canada., Tsoi M; 3College of Veterinary Medicine, Michigan State University, East Lansing, MI., Gerras A; 3College of Veterinary Medicine, Michigan State University, East Lansing, MI., Noll C; 4Woodside Equine Clinic, Ashland, VA., Pinn-Woodcock T; 5College of Veterinary Medicine, Cornell University, Ithaca, NY., Moreira A; 3College of Veterinary Medicine, Michigan State University, East Lansing, MI., Penttila K; 6Burwash Equine Services, Calgary, AB, Canada., Ballou ME; 1College of Veterinary Medicine, North Carolina State University, Raleigh, NC., Dembek KA; 1College of Veterinary Medicine, North Carolina State University, Raleigh, NC., Valberg SJ; 7Valberg Neuromuscular Diagnostic Laboratory, Williamston, MI.
Jazyk:	angličtina
Zdroj:	Journal of the American Veterinary Medical Association [J Am Vet Med Assoc] 2024 Oct 25, pp. 1-11. Date of Electronic Publication: 2024 Oct 25.
DOI:	10.2460/javma.24.08.0522
Abstrakt:	Objective: To describe the clinical findings, outcomes, and muscle histopathology in warmblood horses that developed severe rhabdomyolysis in the perianesthetic period despite remaining stable while under general anesthesia. Animals: 7 warmblood horses, 6 geldings and 1 mare, with a median age of 9 years (range, 4 to 18 years) and median weight of 615 kg (range, 550 to 703 kg). Records from the Valberg Neuromuscular Diagnostic Laboratory and Michigan State University were reviewed (2016 to 2023) to identify warmbloods with postanesthetic myopathy (PAM). Clinical Presentation: Warmblood horses with no history of myopathy developed PAM after remaining stable while under general anesthesia. Five of 7 horses were in regular work prior to anesthesia, and activity level was unknown in 2 horses. Time to standing in recovery was prolonged, 3 horses were euthanized due to persistent recumbency, and rhabdomyolysis recurred in 4 horses 5 to 11 days after anesthesia, with 1 surviving. Horses had muscle stiffness, pain, and sweating and struggled to remain standing. As PAM developed, serum creatine kinase activity and lactate concentrations (12 ± 7 mmol/L; n = 5) were markedly increased. Results: At necropsy, histopathology revealed complete glycogen depletion (5 of 7), acute myodegeneration (6 of 7), and chronic active myodegeneration of representative skeletal muscle samples. A semimembranosus biopsy obtained 14 days after anesthesia from the survivor had rare glycogen-depleted fibers. Clinical Relevance: Warmblood horses are susceptible to fatal PAM characterized by acute myodegeneration, lactic acidosis, and muscle glycogen depletion that occurs up to 11 days after anesthesia. In horses with delayed recovery after anesthesia, monitoring for 2 weeks after anesthesia, including assessment of serum creatine kinase activity and blood lactate, could potentially improve outcomes.
Databáze:	MEDLINE
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