Biochemical analysis of vitreous humor and synovial fluid in the estimation of early postmortem interval: A meta-analytical approach.

Autor: Vieira RB; Graduate Program in Pathology, Ribeirão Preto Medical School, University of São Paulo, USP, Ribeirão Preto, Brazil; Investigative Pathology Laboratory, Federal University of Sergipe, Sergipe, Brazil. Electronic address: raissa.bastosv@gmail.com., Vicentin-Junior CA; Graduate Program in Pathology, Ribeirão Preto Medical School, University of São Paulo, USP, Ribeirão Preto, Brazil; Investigative Pathology Laboratory, Federal University of Sergipe, Sergipe, Brazil., Damascena NP; Investigative Pathology Laboratory, Federal University of Sergipe, Sergipe, Brazil; Graduate Program in Health Sciences, Federal University of Sergipe, Sergipe, Brazil., Silva MC; National Center for the Dissemination of Forensic Sciences, Brazilian Federal Police, Distrito Federal, Brazil., Araujo APD; National Institute of Criminalistics, Brazilian Federal Police, Distrito Federal, Brazil., da Trindade RQ; Graduate Program in Oral Biology, Piracicaba Dental School, State University of Campinas, UNICAMP, São Paulo, Brazil., Vieira MGDM; Graduate Program in Oral Biology, Piracicaba Dental School, State University of Campinas, UNICAMP, São Paulo, Brazil., Cunha E; Centre for Functional Ecology, Laboratory of Forensic Anthropology, University of Coimbra, Portugal; National Institute of Legal Medicine and Forensic Sciences, Lisbon, Portugal., Deitos AR; National Institute of Criminalistics, Brazilian Federal Police, Distrito Federal, Brazil., Santiago BM; Graduate Program in Dentistry, Federal University of Paraiba, Paraiba, Brazil., Martins-Filho PR; Investigative Pathology Laboratory, Federal University of Sergipe, Sergipe, Brazil; Graduate Program in Health Sciences, Federal University of Sergipe, Sergipe, Brazil., Machado CEP; Graduate Program in Pathology, Ribeirão Preto Medical School, University of São Paulo, USP, Ribeirão Preto, Brazil; National Institute of Criminalistics, Brazilian Federal Police, Distrito Federal, Brazil.
Jazyk: angličtina
Zdroj: Journal of forensic and legal medicine [J Forensic Leg Med] 2024 Nov; Vol. 108, pp. 102782. Date of Electronic Publication: 2024 Oct 22.
DOI: 10.1016/j.jflm.2024.102782
Abstrakt: The estimation of the postmortem interval (PMI) is a significant challenge in legal medicine and forensic sciences due to the dynamic and continuous decomposition of organisms after death. Thanatochemistry has emerged as a promising area to estimate PMI by measuring the concentrations of postmortem biochemical markers. This systematic review and meta-analysis aimed to summarize evidence on postmortem biochemical alterations in vitreous humor (VH) and synovial fluid (SF) to estimate early PMI. Comprehensive searches of electronic databases identified studies measuring postmortem biomarker concentrations in both matrices. Our analysis included three meta-analytical approaches: calculating standardized mean differences to assess variations in biochemical parameters, executing correlation meta-analysis (ρ) to explore relationships between these parameters and PMI, and conducting meta-regression to derive a predictive model. Results from five eligible studies indicated no correlation between sodium levels and PMI in both matrices. However, a strong correlation was found between potassium levels and PMI in VH (ρ = 0.69; 95 % CI 0.52 to 0.86) and SF (ρ = 0.81; 95 % CI 0.75 to 0.87), with the meta-regression yielding the optimal predictive equation for SF: [K+] = 6.15 + 0.21 × PMI. These findings support the use of potassium as a reliable biomarker for PMI estimation, particularly in SF.
(Copyright © 2024 Elsevier Ltd and Faculty of Forensic and Legal Medicine. All rights reserved.)
Databáze: MEDLINE
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