Exposure to ambient particulate matter and ovarian reserve impairment among reproductive age women in China.

Autor: Han Z; School of Public Health, Capital Medical University, Beijing 100069, China., Liu J; School of Public Health, Capital Medical University, Beijing 100069, China., Liang T; School of Public Health, Capital Medical University, Beijing 100069, China., Yin J; School of Public Health, Capital Medical University, Beijing 100069, China., Wei J; Department of Atmospheric and Oceanic Science, Earth System Science Interdisciplinary Center, University of Maryland, College Park, MD 20740, USA., Zeng Q; Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China., Cao W; Department of Social Medicine and Health Education, School of Public Health, Peking University, Beijing 100191, China., Liu C; NHC Key Laboratory of Birth Defects and Reproductive Health, Chongqing Population and Family Planning Science and Technology Research Institute, Chongqing, China. Electronic address: cj_514@163.com., Sun S; School of Public Health, Capital Medical University, Beijing 100069, China. Electronic address: Shengzhisun@ccmu.edu.cn.
Jazyk: angličtina
Zdroj: Journal of hazardous materials [J Hazard Mater] 2024 Dec 05; Vol. 480, pp. 136212. Date of Electronic Publication: 2024 Oct 18.
DOI: 10.1016/j.jhazmat.2024.136212
Abstrakt: Ovarian aging, characterized by a decline in ovarian reserve, is a critical concern in female reproductive health. However, the evidence linking ambient air pollution exposure with ovarian reserve impairment remains limited. We aimed to estimate the association between exposure to fine particulate matter (PM 2.5 ) and respirable particulate matter (PM 10 ) and key indicators of ovarian reserve, including antral follicle count (AFC), ovarian volume (OV), anti-Müllerian hormone (AMH), follicle-stimulating hormone (FSH), estradiol (E2), luteinizing hormone (LH), FSH/LH ratio, and inhibin B (INHB). The cohort consisted of women attending an infertility clinic at the Tongji Reproductive and Environmental (TREE) study between 2018 and 2020. We used multivariate linear and Poisson regression models to estimate the association between PM 2.5 and PM 10 exposure and these ovarian reserve indicators. Our results showed that PM 2.5 and PM 10 exposure were associated with a reduction in AFC and an increase in E2 levels, highlighting the adverse effects of ambient air pollution on ovarian reserve. Our findings have important public health implications, emphasizing the urgent need for interventions to safeguard female reproductive health and reduce exposure to ambient air pollution.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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