Aberrant salience signaling in auditory processing in schizophrenia: Evidence for abnormalities in both sensory processing and emotional reactivity.

Autor: Dewan M; University of Maryland School of Medicine, Baltimore, MD, USA., Campbell Daniels E; University of Maryland School of Medicine, Baltimore, MD, USA., Hunt JE; University of Maryland School of Medicine, Baltimore, MD, USA; Maryland Psychiatric Research Center, Catonsville, MD, USA., Bryant EA; University of Maryland School of Medicine, Baltimore, MD, USA; Maryland Psychiatric Research Center, Catonsville, MD, USA., Trikeriotis SI; University of Maryland School of Medicine, Baltimore, MD, USA; Maryland Psychiatric Research Center, Catonsville, MD, USA., Kelly DL; University of Maryland School of Medicine, Baltimore, MD, USA; Maryland Psychiatric Research Center, Catonsville, MD, USA; Spring Grove Hospital Center, Catonsville, MD, USA., Adams HA; University of Maryland School of Medicine, Baltimore, MD, USA; Maryland Psychiatric Research Center, Catonsville, MD, USA; Spring Grove Hospital Center, Catonsville, MD, USA., Hare SM; University of Maryland School of Medicine, Baltimore, MD, USA; Maryland Psychiatric Research Center, Catonsville, MD, USA., Waltz JA; University of Maryland School of Medicine, Baltimore, MD, USA; Maryland Psychiatric Research Center, Catonsville, MD, USA. Electronic address: jwaltz@som.umaryland.edu.
Jazyk: angličtina
Zdroj: Schizophrenia research [Schizophr Res] 2024 Dec; Vol. 274, pp. 329-336. Date of Electronic Publication: 2024 Oct 24.
DOI: 10.1016/j.schres.2024.09.026
Abstrakt: It has been long known that people with schizophrenia (SZ) have deficits in perceptual processing, including in the auditory domain. Furthermore, they often experience increased emotional responsivity and dysregulation, which further impacts overall functioning. Increased emotional responsivity to auditory stimuli is also seen in people with misophonia, a condition in which specific sounds elicit robust negative emotional responses. Given the role of emotional reactivity and dysregulation in the pathogenesis of SZ, our study investigated whether misophonia symptoms were elevated in SZ, or if people with SZ have a generalized increase in reactivity to sensory information. To explore the link between emotional reactivity to sound and more general aspects emotional reactivity and salience signaling in SZ, we used the Misophonia Questionnaire, the Sensory Processing Scale (SPS), and Aberrant Salience Inventory (ASI) in 30 people with SZ and 28 demographically-matched healthy volunteers (HVs). We found that people with SZ exhibited more emotional behavior associated with misophonia symptoms (specifically, distress in relation to sound) than HVs (t 56  = 4.889, p < 0.001), but did not have elevated rates of misophonia overall. Also, sensory processing abnormalities and heightened emotional responses in people with SZ were not limited to the auditory domain but, rather, extended to all sensory modalities. Our results support the idea that SZ involves dysfunction in salience signaling, regarding auditory stimuli, but that abnormalities in salience signaling in SZ are more domain-general. These results highlight the importance of interventions designed to enhance emotion regulation in patients with SZ regarding stimuli in multiple modalities.
Competing Interests: Declaration of competing interest DLK consults for Alkermes PLC, Karuna Neuroscience, and Janssen Pharmaceuticals, but these relationships played no role in the study design and/or interpretation of the present study's results. None of the authors have any financial conflicts of interest.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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